TY - GEN
T1 - Hemispherical microelectrode array for retinal neural recording
AU - Ha, Yoon Hee
AU - Yoo, Hyun Ji
AU - Jun, Sang Beom
N1 - Funding Information:
ACKNOWLEDGMENT The authors thank TODOC Co., Ltd. for excellent technical assistance. This research was supported by the convergence technology development program for bionic arm through the National Research Foundation of Korea (NRF) funded by the Ministry of Science & ICT (No. 2017M3C1B2085310) and the National Research Foundation of Korea funded by the Ministry of Science, ICT & Future Planning of 2015 (No. 2014K1B1A1073720).
Publisher Copyright:
© 2020 IEEE.
PY - 2020/1
Y1 - 2020/1
N2 - In order to study the neuronal visual encoding process in the retina, ex-vivo animal experiments have been conducted using multi-electrode arrays (MEAs) capable of recording electrical signals from retinal tissues. In the conventional retinal experiments, it is inevitable to flatten the retinal tissue from its original hemispherical shape to form tight attachment to conventional planar electrode arrays or substrates. In the process of deforming the tissue, the retina is subject to mechanical stress, which may cause abnormal physiological reactions. To solve this problem, we present an innovative hemispherical MEAs with a curvature so that the retinal tissue can closely attach to the electrodes without deformation. The proposed MEAs is composed of non-toxic aluminum (A1) foil and elastomeric PDMS substrate. In addition, the fabrication is performed using a simple and inexpensive process. It is expected to stably record the retinal responses from multiple retinal ganglion cells around the optical disc because of the uniform adhesion while maintaining the original shape of the retina.
AB - In order to study the neuronal visual encoding process in the retina, ex-vivo animal experiments have been conducted using multi-electrode arrays (MEAs) capable of recording electrical signals from retinal tissues. In the conventional retinal experiments, it is inevitable to flatten the retinal tissue from its original hemispherical shape to form tight attachment to conventional planar electrode arrays or substrates. In the process of deforming the tissue, the retina is subject to mechanical stress, which may cause abnormal physiological reactions. To solve this problem, we present an innovative hemispherical MEAs with a curvature so that the retinal tissue can closely attach to the electrodes without deformation. The proposed MEAs is composed of non-toxic aluminum (A1) foil and elastomeric PDMS substrate. In addition, the fabrication is performed using a simple and inexpensive process. It is expected to stably record the retinal responses from multiple retinal ganglion cells around the optical disc because of the uniform adhesion while maintaining the original shape of the retina.
KW - Hemispherical
KW - Multi-electrode arrays (MEAs)
KW - PDMS
KW - Retina
UR - http://www.scopus.com/inward/record.url?scp=85083498490&partnerID=8YFLogxK
U2 - 10.1109/ICEIC49074.2020.9051290
DO - 10.1109/ICEIC49074.2020.9051290
M3 - Conference contribution
AN - SCOPUS:85083498490
T3 - 2020 International Conference on Electronics, Information, and Communication, ICEIC 2020
BT - 2020 International Conference on Electronics, Information, and Communication, ICEIC 2020
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2020 International Conference on Electronics, Information, and Communication, ICEIC 2020
Y2 - 19 January 2020 through 22 January 2020
ER -