Hemispherical microelectrode array for retinal neural recording

Yoon Hee Ha, Hyun Ji Yoo, Sang Beom Jun

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

In order to study the neuronal visual encoding process in the retina, ex-vivo animal experiments have been conducted using multi-electrode arrays (MEAs) capable of recording electrical signals from retinal tissues. In the conventional retinal experiments, it is inevitable to flatten the retinal tissue from its original hemispherical shape to form tight attachment to conventional planar electrode arrays or substrates. In the process of deforming the tissue, the retina is subject to mechanical stress, which may cause abnormal physiological reactions. To solve this problem, we present an innovative hemispherical MEAs with a curvature so that the retinal tissue can closely attach to the electrodes without deformation. The proposed MEAs is composed of non-toxic aluminum (A1) foil and elastomeric PDMS substrate. In addition, the fabrication is performed using a simple and inexpensive process. It is expected to stably record the retinal responses from multiple retinal ganglion cells around the optical disc because of the uniform adhesion while maintaining the original shape of the retina.

Original languageEnglish
Title of host publication2020 International Conference on Electronics, Information, and Communication, ICEIC 2020
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781728162898
DOIs
StatePublished - Jan 2020
Event2020 International Conference on Electronics, Information, and Communication, ICEIC 2020 - Barcelona, Spain
Duration: 19 Jan 202022 Jan 2020

Publication series

Name2020 International Conference on Electronics, Information, and Communication, ICEIC 2020

Conference

Conference2020 International Conference on Electronics, Information, and Communication, ICEIC 2020
Country/TerritorySpain
CityBarcelona
Period19/01/2022/01/20

Bibliographical note

Funding Information:
ACKNOWLEDGMENT The authors thank TODOC Co., Ltd. for excellent technical assistance. This research was supported by the convergence technology development program for bionic arm through the National Research Foundation of Korea (NRF) funded by the Ministry of Science & ICT (No. 2017M3C1B2085310) and the National Research Foundation of Korea funded by the Ministry of Science, ICT & Future Planning of 2015 (No. 2014K1B1A1073720).

Publisher Copyright:
© 2020 IEEE.

Keywords

  • Hemispherical
  • Multi-electrode arrays (MEAs)
  • PDMS
  • Retina

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