Hemispherical microelectrode array for ex vivo retinal neural recording

Yoonhee Ha, Hyun Ji Yoo, Soowon Shin, Sang Beom Jun

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


To investigate the neuronal visual encoding process in the retina, researchers have performed in vitro and ex vivo electrophysiological experiments using animal retinal tissues. The microelectrode array (MEA) has become a key component in retinal experiments because it enables simultaneous neural recording from a population of retinal neurons. However, in most retinal experiments, it is inevitable that the retinal tissue is flattened on the planar MEA, becoming deformed from the original hemispherical shape. During the tissue deforming process, the retina is subjected to mechanical stress, which can induce abnormal physiological conditions. To overcome this problem, in this study, we propose a hemispherical MEA with a curvature that allows retinal tissues to adhere closely to electrodes without tissue deformation. The electrode array is fabricated by stretching a thin, flexible polydimethylsiloxane (PDMS) electrode layer onto a hemispherical substrate. To form micro patterns of electrodes, laser processing is employed instead of conventional thin-film microfabrication processes. The feasibility for neural recording from retinal tissues using this array is shown by conducting ex vivo retinal experiments. We anticipate that the proposed techniques for hemispherical MEAs can be utilized not only for ex vivo retinal studies but also for various flexible electronics.

Original languageEnglish
Article number538
Issue number5
StatePublished - 1 May 2020

Bibliographical note

Publisher Copyright:
© 2020 by the authors.


  • Hemispherical
  • Microelectrode array (MEA)
  • Neural recording
  • Retina


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