TY - JOUR
T1 - Height-specific blood pressure cutoffs for screening elevated and high blood pressure in children and adolescents
T2 - an International Study
AU - Hou, Yaping
AU - Bovet, Pascal
AU - Kelishadi, Roya
AU - Litwin, Mieczysław
AU - Khadilkar, Anuradha
AU - Hong, Young Mi
AU - Nawarycz, Tadeusz
AU - Stawińska-Witoszyńska, Barbara
AU - Aounallah-Skhiri, Hajer
AU - Motlagh, Mohammad Esmaeil
AU - Kim, Hae Soon
AU - Khadilkar, Vaman
AU - Krzyżaniak, Alicja
AU - Ben Romdhane, Habiba
AU - Heshmat, Ramin
AU - Chiplonkar, Shashi
AU - Krzywińska-Wiewiorowska, Małgorzata
AU - Ati, Jalila El
AU - Qorbani, Mostafa
AU - Kajale, Neha
AU - Traissac, Pierre
AU - Ostrowska-Nawarycz, Lidia
AU - Ardalan, Gelayol
AU - Parthasarathy, Lavanya
AU - Yang, Liu
AU - Zhao, Min
AU - Chiolero, Arnaud
AU - Xi, Bo
N1 - Publisher Copyright:
© 2018, The Japanese Society of Hypertension.
PY - 2019/6/1
Y1 - 2019/6/1
N2 - Pediatric blood pressure (BP) reference tables are generally based on sex, age, and height and tend to be cumbersome to use in routine clinical practice. In this study, we aimed to develop a new, height-specific simple BP table according to the international child BP reference table based on sex, age and height and to evaluate its performance using international data. We validated the simple table in a derivation cohort that included 58,899 children and adolescents aged 6–17 years from surveys in 7 countries (China, India, Iran, Korea, Poland, Tunisia, and the United States) and in a validation cohort that included 70,072 participants from three other surveys (China, Poland and Seychelles). The BP cutoff values for the simple table were calculated for eight height categories for both the 90th (“elevated BP”) and 95th (“high BP”) percentiles of BP. The simple table had a high performance to predict high BP compared to the reference table, with high values (boys/girls) of area under the curve (0.94/0.91), sensitivity (88.5%/82.9%), specificity (99.3%/99.7%), positive predictive values (93.9%/97.3%), and negative predictive values (98.5%/97.8%) in the pooled data from 10 studies. The simple table performed similarly well for predicting elevated BP. A simple table based on height only predicts elevated BP and high BP in children and adolescents nearly as well as the international table based on sex, age, and height. This has important implications for simplifying the detection of pediatric high BP in clinical practice.
AB - Pediatric blood pressure (BP) reference tables are generally based on sex, age, and height and tend to be cumbersome to use in routine clinical practice. In this study, we aimed to develop a new, height-specific simple BP table according to the international child BP reference table based on sex, age and height and to evaluate its performance using international data. We validated the simple table in a derivation cohort that included 58,899 children and adolescents aged 6–17 years from surveys in 7 countries (China, India, Iran, Korea, Poland, Tunisia, and the United States) and in a validation cohort that included 70,072 participants from three other surveys (China, Poland and Seychelles). The BP cutoff values for the simple table were calculated for eight height categories for both the 90th (“elevated BP”) and 95th (“high BP”) percentiles of BP. The simple table had a high performance to predict high BP compared to the reference table, with high values (boys/girls) of area under the curve (0.94/0.91), sensitivity (88.5%/82.9%), specificity (99.3%/99.7%), positive predictive values (93.9%/97.3%), and negative predictive values (98.5%/97.8%) in the pooled data from 10 studies. The simple table performed similarly well for predicting elevated BP. A simple table based on height only predicts elevated BP and high BP in children and adolescents nearly as well as the international table based on sex, age, and height. This has important implications for simplifying the detection of pediatric high BP in clinical practice.
KW - adolescents
KW - children
KW - elevated blood pressure
KW - epidemiology
KW - high blood pressure
KW - methodology
UR - http://www.scopus.com/inward/record.url?scp=85059101004&partnerID=8YFLogxK
U2 - 10.1038/s41440-018-0178-2
DO - 10.1038/s41440-018-0178-2
M3 - Article
C2 - 30587855
AN - SCOPUS:85059101004
SN - 0916-9636
VL - 42
SP - 845
EP - 851
JO - Hypertension Research
JF - Hypertension Research
IS - 6
ER -