Abstract
A new diarylheptanoid containing a chalcone moiety, katsumain H (1), was isolated from the seeds of Alpinia katsumadai. The structure was elucidated using a combination of 1D/2D NMR spectroscopy and mass spectrometry data analysis. The absolute configurations of C-3, C-5, and C-7 in 1 were assigned based on its optical rotation and after comparing its NMR chemical shifts with those of its diastereoisomers, katsumain E and katsumain F, which were previously isolated from this plant and characterized. In this study, the stimulatory effects of compounds 1 and 2 were evaluated on heat shock factor 1 (HSF1), heat shock protein 27 (HSP27), and HSP70. Compounds 1 and 2 increased the expression of HSF1 (1.056- and 1.200-fold, respectively), HSP27 (1.312- and 1.242-fold, respectively), and HSP70 (1.234- and 1.271-fold, respectively), without increased cytotoxicity .
| Original language | English |
|---|---|
| Article number | 1750 |
| Journal | Molecules |
| Volume | 22 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 2017 |
Bibliographical note
Funding Information:Acknowledgments: The authors are particularly grateful to Eun-Kyoung Seo (College of Pharmacy, Ewha Womans University, Korea) for her supports and valuable comments on this research study. This work was supported by the 2017 Yeungnam University Research Grant.
Publisher Copyright:
© 2017 by the authors.
Keywords
- Alpinia katsumadai
- Chalcone
- Diarylheptanoid
- Heat shock factor (HSF)
- Heat shock protein (HSP)