TY - JOUR
T1 - Heat shock protein-inducing property of diarylheptanoid containing chalcone moiety from alpinia katsumadai
AU - Nam, Joo Won
AU - Lee, Yun Sil
N1 - Funding Information:
Acknowledgments: The authors are particularly grateful to Eun-Kyoung Seo (College of Pharmacy, Ewha Womans University, Korea) for her supports and valuable comments on this research study. This work was supported by the 2017 Yeungnam University Research Grant.
Publisher Copyright:
© 2017 by the authors.
PY - 2017/10
Y1 - 2017/10
N2 - A new diarylheptanoid containing a chalcone moiety, katsumain H (1), was isolated from the seeds of Alpinia katsumadai. The structure was elucidated using a combination of 1D/2D NMR spectroscopy and mass spectrometry data analysis. The absolute configurations of C-3, C-5, and C-7 in 1 were assigned based on its optical rotation and after comparing its NMR chemical shifts with those of its diastereoisomers, katsumain E and katsumain F, which were previously isolated from this plant and characterized. In this study, the stimulatory effects of compounds 1 and 2 were evaluated on heat shock factor 1 (HSF1), heat shock protein 27 (HSP27), and HSP70. Compounds 1 and 2 increased the expression of HSF1 (1.056- and 1.200-fold, respectively), HSP27 (1.312- and 1.242-fold, respectively), and HSP70 (1.234- and 1.271-fold, respectively), without increased cytotoxicity .
AB - A new diarylheptanoid containing a chalcone moiety, katsumain H (1), was isolated from the seeds of Alpinia katsumadai. The structure was elucidated using a combination of 1D/2D NMR spectroscopy and mass spectrometry data analysis. The absolute configurations of C-3, C-5, and C-7 in 1 were assigned based on its optical rotation and after comparing its NMR chemical shifts with those of its diastereoisomers, katsumain E and katsumain F, which were previously isolated from this plant and characterized. In this study, the stimulatory effects of compounds 1 and 2 were evaluated on heat shock factor 1 (HSF1), heat shock protein 27 (HSP27), and HSP70. Compounds 1 and 2 increased the expression of HSF1 (1.056- and 1.200-fold, respectively), HSP27 (1.312- and 1.242-fold, respectively), and HSP70 (1.234- and 1.271-fold, respectively), without increased cytotoxicity .
KW - Alpinia katsumadai
KW - Chalcone
KW - Diarylheptanoid
KW - Heat shock factor (HSF)
KW - Heat shock protein (HSP)
UR - http://www.scopus.com/inward/record.url?scp=85032706868&partnerID=8YFLogxK
U2 - 10.3390/molecules22101750
DO - 10.3390/molecules22101750
M3 - Article
C2 - 29039794
AN - SCOPUS:85032706868
VL - 22
JO - Molecules
JF - Molecules
SN - 1420-3049
IS - 10
M1 - 1750
ER -