Heat shock factor 1 inducers from the bark of Eucommia ulmoides as cytoprotective agents

Joo Won Nam, Seo Young Kim, Taesook Yoon, Yoo Jin Lee, Yun Seo Kil, Yun Sil Lee, Eun Kyoung Seo

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

The barks of Eucommia ulmoides (Eucommiae Cortex, Eucommiaceae) have been used as a traditional medicine in Korea, Japan, and China to treat hypertension, reinforce the muscles and bones, and recover the damaged liver and kidney functions. Among these traditional uses, to establish the recovery effects on the damaged organs on the basis of phytochemistry, the barks of E. ulmoides have been investigated to afford three known phenolic compounds, coniferaldehyde glucoside (1), bartsioside (2), and feretoside (3), which were found in the family Eucommiaceae for the first time. The compounds 1-3 were evaluated for their inducible activities on the heat shock factor 1 (HSF1), and heat shock proteins (HSPs) 27 and 70, along with four compounds, geniposide (4), geniposidic acid (5), pinoresinol diglucoside (6), and liriodendrin (7), which were previously reported from E. ulmoides. Compounds 1-7 increased expression of HSF1 by a factor of 1.214, 1.144, 1.153, 1.114, 1.159, 1.041, and 1.167 at 3 μM, respectively. Coniferaldehyde glucoside (1) showed the most effective increase of HSF1 and induced successive expressions of HSP27 and HSP70 in a dose-dependent manner without cellular cytotoxicity, suggesting a possible application as a HSP inducer to act as cytoprotective agent.

Original languageEnglish
Pages (from-to)1322-1327
Number of pages6
JournalChemistry and Biodiversity
Volume10
Issue number7
DOIs
StatePublished - Jul 2013

Keywords

  • Coniferaldehyde
  • Cytoprotective activity
  • Eucommia ulmoides
  • Glucosides
  • Heat shock factor

Fingerprint

Dive into the research topics of 'Heat shock factor 1 inducers from the bark of Eucommia ulmoides as cytoprotective agents'. Together they form a unique fingerprint.

Cite this