Health-Related Quality of Life and Its Determinants in Chronic Cough: The Korean Chronic Cough Registry Study

Noeul Kang; Ha Kyeong Won; Ji Hyang Lee; Ji Su Shim; Sung Yoon Kang; Han Ki Park; Eun Jung Jo; Seung Eun Lee; Min Hye Kim; Sang Heon Kim; Sae Hoon Kim; Yoon Seok Chang; Byung Jae Lee; Woo Jung Song; Min Woo Jo

doi:10.4168/aair.2023.15.3.348

Health-Related Quality of Life and Its Determinants in Chronic Cough: The Korean Chronic Cough Registry Study

Noeul Kang, Ha Kyeong Won, Ji Hyang Lee, Ji Su Shim, Sung Yoon Kang, Han Ki Park, Eun Jung Jo, Seung Eun Lee, Min Hye Kim, Sang Heon Kim, Sae Hoon Kim, Yoon Seok Chang, Byung Jae Lee, Woo Jung Song, Min Woo Jo

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Purpose: Chronic cough (CC) is associated with health-related quality of life (HRQoL) impairment. However, the determinants of HRQoL are under-investigated. Methods: Patients aged 19–80 years with CC were prospectively recruited from 10 referral clinics. Comparisons were made with age- and sex-matched controls (1:4 ratio) selected from a Korean general population survey database; 1) a group without current cough (non-cough controls) and 2) another group without major chronic illnesses (healthy controls). HRQoL was assessed using the EuroQoL 5-dimension (EQ-5D) index. In CC patients, cough-specific patient-reported outcomes (PROs) were additionally measured. Cross-sectional analyses were performed to evaluate demographic and clinical parameters associated with the EQ-5D index of CC patients. Results: A total of 200 CC patients (137 newly referred with CC and 63 refractory or unexplained CC [RUCC] patients), 800 non-cough controls, and 799 healthy controls were analyzed. The EQ-5D index of CC patients was significantly lower than that of non-cough controls or healthy controls (0.82 ± 0.14 vs 0.92 ± 0.14/0.96 ± 0.08; P < 0.001, respectively). The index was also associated with older age (≥ 60 years), female sex, and comorbidities such as asthma or depression. Among the patients with CC, the index was significantly lower in patients with RUCC than in those with newly referred CC, being treated with codeine or cough neuromodulators, or with cough-related fatigue. In Spearman analyses, the EQ-5D index correlated with cough-specific quality of life and cough severity scores, not with throat sensation or cough trigger scores. Conclusions: The HRQoL impairment of CC patients was associated with older age, female sex, and comorbidities but it was also affected by cough severity, complications, treatments, and treatment responses. Longitudinal studies are warranted to further understand and improve the HRQoL of CC patients.

Original language	English
Pages (from-to)	348-360
Number of pages	13
Journal	Allergy, Asthma and Immunology Research
Volume	15
Issue number	3
DOIs	https://doi.org/10.4168/aair.2023.15.3.348
State	Published - May 2023

Bibliographical note

Publisher Copyright:
Copyright © 2023 The Korean Academy of Asthma, Allergy and Clinical Immunology.

Keywords

cost of illness
cough
health status
quality of life
registries

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10.4168/aair.2023.15.3.348

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Kang, N., Won, H. K., Lee, J. H., Shim, J. S., Kang, S. Y., Park, H. K., Jo, E. J., Lee, S. E., Kim, M. H., Kim, S. H., Kim, S. H., Chang, Y. S., Lee, B. J., Song, W. J., & Jo, M. W. (2023). Health-Related Quality of Life and Its Determinants in Chronic Cough: The Korean Chronic Cough Registry Study. Allergy, Asthma and Immunology Research, 15(3), 348-360. https://doi.org/10.4168/aair.2023.15.3.348

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title = "Health-Related Quality of Life and Its Determinants in Chronic Cough: The Korean Chronic Cough Registry Study",

abstract = "Purpose: Chronic cough (CC) is associated with health-related quality of life (HRQoL) impairment. However, the determinants of HRQoL are under-investigated. Methods: Patients aged 19–80 years with CC were prospectively recruited from 10 referral clinics. Comparisons were made with age- and sex-matched controls (1:4 ratio) selected from a Korean general population survey database; 1) a group without current cough (non-cough controls) and 2) another group without major chronic illnesses (healthy controls). HRQoL was assessed using the EuroQoL 5-dimension (EQ-5D) index. In CC patients, cough-specific patient-reported outcomes (PROs) were additionally measured. Cross-sectional analyses were performed to evaluate demographic and clinical parameters associated with the EQ-5D index of CC patients. Results: A total of 200 CC patients (137 newly referred with CC and 63 refractory or unexplained CC [RUCC] patients), 800 non-cough controls, and 799 healthy controls were analyzed. The EQ-5D index of CC patients was significantly lower than that of non-cough controls or healthy controls (0.82 ± 0.14 vs 0.92 ± 0.14/0.96 ± 0.08; P < 0.001, respectively). The index was also associated with older age (≥ 60 years), female sex, and comorbidities such as asthma or depression. Among the patients with CC, the index was significantly lower in patients with RUCC than in those with newly referred CC, being treated with codeine or cough neuromodulators, or with cough-related fatigue. In Spearman analyses, the EQ-5D index correlated with cough-specific quality of life and cough severity scores, not with throat sensation or cough trigger scores. Conclusions: The HRQoL impairment of CC patients was associated with older age, female sex, and comorbidities but it was also affected by cough severity, complications, treatments, and treatment responses. Longitudinal studies are warranted to further understand and improve the HRQoL of CC patients.",

keywords = "cost of illness, cough, health status, quality of life, registries",

author = "Noeul Kang and Won, {Ha Kyeong} and Lee, {Ji Hyang} and Shim, {Ji Su} and Kang, {Sung Yoon} and Park, {Han Ki} and Jo, {Eun Jung} and Lee, {Seung Eun} and Kim, {Min Hye} and Kim, {Sang Heon} and Kim, {Sae Hoon} and Chang, {Yoon Seok} and Lee, {Byung Jae} and Song, {Woo Jung} and Jo, {Min Woo}",

note = "Publisher Copyright: Copyright {\textcopyright} 2023 The Korean Academy of Asthma, Allergy and Clinical Immunology.",

year = "2023",

month = may,

doi = "10.4168/aair.2023.15.3.348",

language = "English",

volume = "15",

pages = "348--360",

journal = "Allergy, Asthma and Immunology Research",

issn = "2092-7355",

publisher = "Korean Academy of Asthma, Allergy and Clinical Immunology",

number = "3",

}

Kang, N, Won, HK, Lee, JH, Shim, JS, Kang, SY, Park, HK, Jo, EJ, Lee, SE, Kim, MH, Kim, SH, Kim, SH, Chang, YS, Lee, BJ, Song, WJ & Jo, MW 2023, 'Health-Related Quality of Life and Its Determinants in Chronic Cough: The Korean Chronic Cough Registry Study', Allergy, Asthma and Immunology Research, vol. 15, no. 3, pp. 348-360. https://doi.org/10.4168/aair.2023.15.3.348

TY - JOUR

T1 - Health-Related Quality of Life and Its Determinants in Chronic Cough

T2 - The Korean Chronic Cough Registry Study

AU - Kang, Noeul

AU - Won, Ha Kyeong

AU - Lee, Ji Hyang

AU - Shim, Ji Su

AU - Kang, Sung Yoon

AU - Park, Han Ki

AU - Jo, Eun Jung

AU - Lee, Seung Eun

AU - Kim, Min Hye

AU - Kim, Sang Heon

AU - Kim, Sae Hoon

AU - Chang, Yoon Seok

AU - Lee, Byung Jae

AU - Song, Woo Jung

AU - Jo, Min Woo

PY - 2023/5

Y1 - 2023/5

N2 - Purpose: Chronic cough (CC) is associated with health-related quality of life (HRQoL) impairment. However, the determinants of HRQoL are under-investigated. Methods: Patients aged 19–80 years with CC were prospectively recruited from 10 referral clinics. Comparisons were made with age- and sex-matched controls (1:4 ratio) selected from a Korean general population survey database; 1) a group without current cough (non-cough controls) and 2) another group without major chronic illnesses (healthy controls). HRQoL was assessed using the EuroQoL 5-dimension (EQ-5D) index. In CC patients, cough-specific patient-reported outcomes (PROs) were additionally measured. Cross-sectional analyses were performed to evaluate demographic and clinical parameters associated with the EQ-5D index of CC patients. Results: A total of 200 CC patients (137 newly referred with CC and 63 refractory or unexplained CC [RUCC] patients), 800 non-cough controls, and 799 healthy controls were analyzed. The EQ-5D index of CC patients was significantly lower than that of non-cough controls or healthy controls (0.82 ± 0.14 vs 0.92 ± 0.14/0.96 ± 0.08; P < 0.001, respectively). The index was also associated with older age (≥ 60 years), female sex, and comorbidities such as asthma or depression. Among the patients with CC, the index was significantly lower in patients with RUCC than in those with newly referred CC, being treated with codeine or cough neuromodulators, or with cough-related fatigue. In Spearman analyses, the EQ-5D index correlated with cough-specific quality of life and cough severity scores, not with throat sensation or cough trigger scores. Conclusions: The HRQoL impairment of CC patients was associated with older age, female sex, and comorbidities but it was also affected by cough severity, complications, treatments, and treatment responses. Longitudinal studies are warranted to further understand and improve the HRQoL of CC patients.

AB - Purpose: Chronic cough (CC) is associated with health-related quality of life (HRQoL) impairment. However, the determinants of HRQoL are under-investigated. Methods: Patients aged 19–80 years with CC were prospectively recruited from 10 referral clinics. Comparisons were made with age- and sex-matched controls (1:4 ratio) selected from a Korean general population survey database; 1) a group without current cough (non-cough controls) and 2) another group without major chronic illnesses (healthy controls). HRQoL was assessed using the EuroQoL 5-dimension (EQ-5D) index. In CC patients, cough-specific patient-reported outcomes (PROs) were additionally measured. Cross-sectional analyses were performed to evaluate demographic and clinical parameters associated with the EQ-5D index of CC patients. Results: A total of 200 CC patients (137 newly referred with CC and 63 refractory or unexplained CC [RUCC] patients), 800 non-cough controls, and 799 healthy controls were analyzed. The EQ-5D index of CC patients was significantly lower than that of non-cough controls or healthy controls (0.82 ± 0.14 vs 0.92 ± 0.14/0.96 ± 0.08; P < 0.001, respectively). The index was also associated with older age (≥ 60 years), female sex, and comorbidities such as asthma or depression. Among the patients with CC, the index was significantly lower in patients with RUCC than in those with newly referred CC, being treated with codeine or cough neuromodulators, or with cough-related fatigue. In Spearman analyses, the EQ-5D index correlated with cough-specific quality of life and cough severity scores, not with throat sensation or cough trigger scores. Conclusions: The HRQoL impairment of CC patients was associated with older age, female sex, and comorbidities but it was also affected by cough severity, complications, treatments, and treatment responses. Longitudinal studies are warranted to further understand and improve the HRQoL of CC patients.

KW - cost of illness

KW - cough

KW - health status

KW - quality of life

KW - registries

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U2 - 10.4168/aair.2023.15.3.348

DO - 10.4168/aair.2023.15.3.348

M3 - Article

AN - SCOPUS:85160848481

SN - 2092-7355

VL - 15

SP - 348

EP - 360

JO - Allergy, Asthma and Immunology Research

JF - Allergy, Asthma and Immunology Research

IS - 3

ER -

Health-Related Quality of Life and Its Determinants in Chronic Cough: The Korean Chronic Cough Registry Study

Abstract

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