Harmonic acoustics for dynamic and selective particle manipulation

Shujie Yang; Zhenhua Tian; Zeyu Wang; Joseph Rufo; Peng Li; John Mai; Jianping Xia; Hunter Bachman; Po Hsun Huang; Mengxi Wu; Chuyi Chen; Luke P. Lee; Tony Jun Huang

doi:10.1038/s41563-022-01210-8

Harmonic acoustics for dynamic and selective particle manipulation

Shujie Yang, Zhenhua Tian, Zeyu Wang, Joseph Rufo, Peng Li, John Mai, Jianping Xia, Hunter Bachman, Po Hsun Huang, Mengxi Wu, Chuyi Chen, Luke P. Lee, Tony Jun Huang

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

94 Scopus citations

Abstract

Precise and selective manipulation of colloids and biological cells has long been motivated by applications in materials science, physics and the life sciences. Here we introduce our harmonic acoustics for a non-contact, dynamic, selective (HANDS) particle manipulation platform, which enables the reversible assembly of colloidal crystals or cells via the modulation of acoustic trapping positions with subwavelength resolution. We compose Fourier-synthesized harmonic waves to create soft acoustic lattices and colloidal crystals without using surface treatment or modifying their material properties. We have achieved active control of the lattice constant to dynamically modulate the interparticle distance in a high-throughput (>100 pairs), precise, selective and reversible manner. Furthermore, we apply this HANDS platform to quantify the intercellular adhesion forces among various cancer cell lines. Our biocompatible HANDS platform provides a highly versatile particle manipulation method that can handle soft matter and measure the interaction forces between living cells with high sensitivity.

Original language	English
Pages (from-to)	540-546
Number of pages	7
Journal	Nature Materials
Volume	21
Issue number	5
DOIs	https://doi.org/10.1038/s41563-022-01210-8
State	Published - May 2022

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Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Nature Limited.

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title = "Harmonic acoustics for dynamic and selective particle manipulation",

abstract = "Precise and selective manipulation of colloids and biological cells has long been motivated by applications in materials science, physics and the life sciences. Here we introduce our harmonic acoustics for a non-contact, dynamic, selective (HANDS) particle manipulation platform, which enables the reversible assembly of colloidal crystals or cells via the modulation of acoustic trapping positions with subwavelength resolution. We compose Fourier-synthesized harmonic waves to create soft acoustic lattices and colloidal crystals without using surface treatment or modifying their material properties. We have achieved active control of the lattice constant to dynamically modulate the interparticle distance in a high-throughput (>100 pairs), precise, selective and reversible manner. Furthermore, we apply this HANDS platform to quantify the intercellular adhesion forces among various cancer cell lines. Our biocompatible HANDS platform provides a highly versatile particle manipulation method that can handle soft matter and measure the interaction forces between living cells with high sensitivity.",

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AU - Yang, Shujie

AU - Tian, Zhenhua

AU - Wang, Zeyu

AU - Rufo, Joseph

AU - Li, Peng

AU - Mai, John

AU - Xia, Jianping

AU - Bachman, Hunter

AU - Huang, Po Hsun

AU - Wu, Mengxi

AU - Chen, Chuyi

AU - Lee, Luke P.

AU - Huang, Tony Jun

PY - 2022/5

Y1 - 2022/5

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AB - Precise and selective manipulation of colloids and biological cells has long been motivated by applications in materials science, physics and the life sciences. Here we introduce our harmonic acoustics for a non-contact, dynamic, selective (HANDS) particle manipulation platform, which enables the reversible assembly of colloidal crystals or cells via the modulation of acoustic trapping positions with subwavelength resolution. We compose Fourier-synthesized harmonic waves to create soft acoustic lattices and colloidal crystals without using surface treatment or modifying their material properties. We have achieved active control of the lattice constant to dynamically modulate the interparticle distance in a high-throughput (>100 pairs), precise, selective and reversible manner. Furthermore, we apply this HANDS platform to quantify the intercellular adhesion forces among various cancer cell lines. Our biocompatible HANDS platform provides a highly versatile particle manipulation method that can handle soft matter and measure the interaction forces between living cells with high sensitivity.

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Harmonic acoustics for dynamic and selective particle manipulation

Abstract

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UN SDGs

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