Harmonic acoustics for dynamic and selective particle manipulation

Shujie Yang, Zhenhua Tian, Zeyu Wang, Joseph Rufo, Peng Li, John Mai, Jianping Xia, Hunter Bachman, Po Hsun Huang, Mengxi Wu, Chuyi Chen, Luke P. Lee, Tony Jun Huang

Research output: Contribution to journalArticlepeer-review

65 Scopus citations


Precise and selective manipulation of colloids and biological cells has long been motivated by applications in materials science, physics and the life sciences. Here we introduce our harmonic acoustics for a non-contact, dynamic, selective (HANDS) particle manipulation platform, which enables the reversible assembly of colloidal crystals or cells via the modulation of acoustic trapping positions with subwavelength resolution. We compose Fourier-synthesized harmonic waves to create soft acoustic lattices and colloidal crystals without using surface treatment or modifying their material properties. We have achieved active control of the lattice constant to dynamically modulate the interparticle distance in a high-throughput (>100 pairs), precise, selective and reversible manner. Furthermore, we apply this HANDS platform to quantify the intercellular adhesion forces among various cancer cell lines. Our biocompatible HANDS platform provides a highly versatile particle manipulation method that can handle soft matter and measure the interaction forces between living cells with high sensitivity.

Original languageEnglish
Pages (from-to)540-546
Number of pages7
JournalNature Materials
Issue number5
StatePublished - May 2022

Bibliographical note

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© 2022, The Author(s), under exclusive licence to Springer Nature Limited.


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