Group-and home-based cognitive intervention for patients with mild cognitive impairment: A randomized controlled trial

Jee Hyang Jeong, Hae Ri Na, Seong Hye Choi, Jungeun Kim, Duk L. Na, Sang Won Seo, Juhee Chin, Sun Ah Park, Eun Joo Kim, Hyun Jeong Han, Seol Heui Han, Soo Jin Yoon, Jae Hong Lee, Kyung Won Park, So Young Moon, Moon Ho Park, Mun Seong Choi, Il Woo Han, Jun Hong Lee, Jung Seok LeeYong S. Shim, Jeong Yeon Kim

Research output: Contribution to journalArticlepeer-review

57 Scopus citations


Background: We examined the efficacy of group-based cognitive intervention (GCI) and home-based cognitive intervention (HCI) in amnestic mild cognitive impairment (aMCI) and intervention effects on serum brain-derived neuro- trophic factor (BDNF). Methods: In this randomized and rater- blinded trial, 293 patients with aMCI from 18 nationwide hospitals were randomized: 96 to the GCI group, 98 to the HCI group and 99 to the control group. For 12 weeks, subjects receiving GCI participated twice per week in group sessions led by trained instructors, and those receiving HCI completed homework materials 5 days per week. They were assessed at baseline, postintervention (PI) and at the 6-month follow-up after the intervention. The primary endpoint was the change from baseline to PI in the modified Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-Cog). Results: In comparison to the controls (a 0.8-point decrease), the subjects receiving GCI (a 2.3-point decrease, p = 0.01) or HCI (a 2.5-point decrease, p = 0.02) showed significant improvements in the modified ADAS-Cog at PI, respectively. By the 6-month follow-up, those receiving GCI or HCI had better scores in the m odified ADAS-Cog than the controls. The changes in BDNF levels significantly correlated with the changes in the modified ADAS-Cog in the GCI (r = '0.29, p = 0.02 at PI) and HCI (r = '0.27, p = 0.03 at 6-month follow-up) groups, respectively. Conclusions: The GCI and HCI resulted in cognitive improvements in aMCI. An enhanced brain plasticity may be a component of the mechanism underpinning the cognitive improvements associated with the cognitive interventions.

Original languageEnglish
Pages (from-to)198-207
Number of pages10
JournalPsychotherapy and Psychosomatics
Issue number4
StatePublished - 14 Jun 2016

Bibliographical note

Publisher Copyright:
© 2016 The Author(s) Published by S. Karger AG, Basel.


  • Brain plasticity
  • Brain-derived neurotrophic factor
  • Cognition training
  • Conitive intervention
  • Mild cognitive impairment


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