Gold(I)-catalyzed tandem synthesis of polycyclic dihydroquinazolinones

Jingyang Sun; Yoona Song; Jae Sang Ryu

doi:10.3390/catal11121436

Gold(I)-catalyzed tandem synthesis of polycyclic dihydroquinazolinones

Jingyang Sun, Yoona Song, Jae Sang Ryu

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

A gold-catalyzed cascade process for the synthesis of dihydroquinazolinone scaffolds was developed. A series of gold catalysts were screened for this tandem transformation, and the (PPh3)AuCl/AgOTf catalyst combination was found to be the best catalyst system. This method is characterized by good yields, high regioselectivity, and broad substrate scope. This method is also applicable to the synthesis of tetracyclic dihydroquinazolinones and seven-membered ring-fused dihydroquinazolinones.

Original language	English
Article number	1436
Journal	Catalysts
Volume	11
Issue number	12
DOIs	https://doi.org/10.3390/catal11121436
State	Published - Dec 2021

Bibliographical note

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

Cascade reaction
Dihydroquinazolinone
Gold
Silver
Tandem reaction

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10.3390/catal11121436

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title = "Gold(I)-catalyzed tandem synthesis of polycyclic dihydroquinazolinones",

abstract = "A gold-catalyzed cascade process for the synthesis of dihydroquinazolinone scaffolds was developed. A series of gold catalysts were screened for this tandem transformation, and the (PPh3)AuCl/AgOTf catalyst combination was found to be the best catalyst system. This method is characterized by good yields, high regioselectivity, and broad substrate scope. This method is also applicable to the synthesis of tetracyclic dihydroquinazolinones and seven-membered ring-fused dihydroquinazolinones.",

keywords = "Cascade reaction, Dihydroquinazolinone, Gold, Silver, Tandem reaction",

author = "Jingyang Sun and Yoona Song and Ryu, {Jae Sang}",

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AU - Sun, Jingyang

AU - Song, Yoona

AU - Ryu, Jae Sang

PY - 2021/12

Y1 - 2021/12

N2 - A gold-catalyzed cascade process for the synthesis of dihydroquinazolinone scaffolds was developed. A series of gold catalysts were screened for this tandem transformation, and the (PPh3)AuCl/AgOTf catalyst combination was found to be the best catalyst system. This method is characterized by good yields, high regioselectivity, and broad substrate scope. This method is also applicable to the synthesis of tetracyclic dihydroquinazolinones and seven-membered ring-fused dihydroquinazolinones.

AB - A gold-catalyzed cascade process for the synthesis of dihydroquinazolinone scaffolds was developed. A series of gold catalysts were screened for this tandem transformation, and the (PPh3)AuCl/AgOTf catalyst combination was found to be the best catalyst system. This method is characterized by good yields, high regioselectivity, and broad substrate scope. This method is also applicable to the synthesis of tetracyclic dihydroquinazolinones and seven-membered ring-fused dihydroquinazolinones.

KW - Cascade reaction

KW - Dihydroquinazolinone

KW - Gold

KW - Silver

KW - Tandem reaction

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JO - Catalysts

JF - Catalysts

IS - 12

M1 - 1436

ER -

Gold(I)-catalyzed tandem synthesis of polycyclic dihydroquinazolinones

Abstract

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Keywords

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