Gold(I)-catalyzed tandem synthesis of polycyclic dihydroquinazolinones

Jingyang Sun, Yoona Song, Jae Sang Ryu

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


A gold-catalyzed cascade process for the synthesis of dihydroquinazolinone scaffolds was developed. A series of gold catalysts were screened for this tandem transformation, and the (PPh3)AuCl/AgOTf catalyst combination was found to be the best catalyst system. This method is characterized by good yields, high regioselectivity, and broad substrate scope. This method is also applicable to the synthesis of tetracyclic dihydroquinazolinones and seven-membered ring-fused dihydroquinazolinones.

Original languageEnglish
Article number1436
Issue number12
StatePublished - Dec 2021

Bibliographical note

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.


  • Cascade reaction
  • Dihydroquinazolinone
  • Gold
  • Silver
  • Tandem reaction


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