Gold(I)-Catalyzed Intramolecular Dehydrative Amination of Sulfamate Esters Tethered to Allylic Alcohols: A Strategy for the Synthesis of Cyclic Sulfamidates

Yunjeong Park, Ji Sun Lee, Jae Sang Ryu

Research output: Contribution to journalArticlepeer-review

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Abstract

An efficient synthesis protocol for cyclic sulfamidates has been developed via catalytic intramolecular cyclizations of sulfamate esters tethered to allylic alcohols. The reactions proceed smoothly at room temperature in the presence of (IPr)AuCl (5 mol%) and AgBF4 (5 mol%). This protocol features good to excellent yields, high selectivity, broad substrate scope, and mild reaction conditions. This method is also applicable to the synthesis of a seven-membered sulfamidate. (Figure presented.).

Original languageEnglish
Pages (from-to)2183-2188
Number of pages6
JournalAdvanced Synthesis and Catalysis
Volume363
Issue number8
DOIs
StatePublished - 13 Apr 2021

Keywords

  • Amination
  • Cyclic sulfamidate
  • Gold
  • Homogeneous catalysis
  • Silver

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