Gold nanoparticle (AuNP)-based drug delivery and molecular imaging for biomedical applications

Eun Hye Jeong, Giyoung Jung, Cheol Am Hong, Hyukjin Lee

Research output: Contribution to journalReview articlepeer-review

90 Scopus citations

Abstract

Gold nanoparticles (AuNPs) can be readily synthesized and modified with chemical and biological molecules, making them attractive inorganic biomaterials for drug delivery and molecular diagnostics. The surface of AuNPs supports the efficient attachment of various biomacromolecules via chemisorption, chemical conjugation and electrostatic interaction. Based on advantages of facile surface modification and unique optical properties, AuNPs have been extensively used as drug carriers for the intracellular delivery of therapeutics as well as molecular nanoprobes for detection and monitoring of the target molecules of interest. In this review, we highlight advanced approaches in the biomedical applications of AuNPs such as gene and drug therapy, molecular diagnostics and imaging.

Original languageEnglish
Pages (from-to)53-59
Number of pages7
JournalArchives of Pharmacal Research
Volume37
Issue number1
DOIs
StatePublished - Jan 2014

Bibliographical note

Funding Information:
Acknowledgments This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (NRF-2012R1A1A1039030) and the Ewha Womans University Research Grant of 2013.

Keywords

  • Gene and drug therapy
  • Gold nanoparticles (AuNPs)
  • Intracellular drug delivery
  • Molecular diagnostics and imaging

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