Catalytic intramolecular additions of hydroxyl groups to tethered conjugated dienes are described. The reactions proceed smoothly at 60 °C in the presence of 5 mol % of (PPh 3)AuCl/AgOTf as a catalyst. A broad range of structurally diverse conjugated dienes produce substituted tetrahydrofurans and tetrahydropyrans in good yields. This reaction represents an atom-economic route to construct five- and six-membered cyclic ethers.
Bibliographical noteFunding Information:
This work was supported by the grant from the National Core Research Center Program (No. 2012-0000952 ) of the Ministry of Science & Technology and by the Ewha Global Top5 Grant 2011 of Ewha Womans University .
- Conjugated diene