@article{95ecf5fd90924279a3d6eb065609dd2c,
title = "GMP and IMP are competitive inhibitors of CMY-10, an extended-spectrum class C β-lactamase",
abstract = "Nucleotides were effective in inhibiting the class C β-lactamase CMY-10. IMP was the most potent competitive inhibitor, with a Ki value of 16.2 μM. The crystal structure of CMY-10 complexed with GMP or IMP revealed that nucleotides fit into the R2 subsite of the active site with a unique vertical binding mode where the phosphate group at one terminus is deeply bound in the subsite and the base at the other terminus faces the solvent.",
keywords = "Competitive inhibitor, GMP, IMP, β-lactamases",
author = "Na, {Jung Hyun} and An, {Young Jun} and Cha, {Sun Shin}",
note = "Funding Information: This study was supported by the National Research Foundation of Korea grants (NRF-2015R1A2A2A01004168 and NRF-2015M1A5A1037480) and by a grant from Marine Biotechnology Program (PJT200620) funded by Ministry of Oceans and Fisheries, South Korea Publisher Copyright: Copyright {\textcopyright} 2017 American Society for Microbiology. All Rights Reserved.",
year = "2017",
month = may,
doi = "10.1128/AAC.00098-17",
language = "English",
volume = "61",
journal = "Antimicrobial Agents and Chemotherapy",
issn = "0066-4804",
publisher = "American Society for Microbiology",
number = "5",
}