Glycan-targeted virus-like nanoparticles for photodynamic therapy

Jin Kyu Rhee; Michael Baksh; Corwin Nycholat; James C. Paulson; Hiroaki Kitagishi; M. G. Finn

doi:10.1021/bm300578p

Glycan-targeted virus-like nanoparticles for photodynamic therapy

Jin Kyu Rhee, Michael Baksh, Corwin Nycholat, James C. Paulson, Hiroaki Kitagishi, M. G. Finn

Department of Food Science & Biotechnology

Research output: Contribution to journal › Article › peer-review

90 Scopus citations

Abstract

Virus-like particles (VLPs) have proven to be versatile platforms for chemical and genetic functionalization for a variety of purposes in biomedicine, catalysis, and materials science. We describe here the simultaneous modification of the bacteriophage Qβ VLP with a metalloporphyrin derivative for photodynamic therapy and a glycan ligand for specific targeting of cells bearing the CD22 receptor. This application benefits from the presence of the targeting function and the delivery of a high local concentration of singlet oxygen-generating payload.

Original language	English
Pages (from-to)	2333-2338
Number of pages	6
Journal	Biomacromolecules
Volume	13
Issue number	8
DOIs	https://doi.org/10.1021/bm300578p
State	Published - 13 Aug 2012

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AU - Baksh, Michael

AU - Nycholat, Corwin

AU - Paulson, James C.

AU - Kitagishi, Hiroaki

AU - Finn, M. G.

PY - 2012/8/13

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AB - Virus-like particles (VLPs) have proven to be versatile platforms for chemical and genetic functionalization for a variety of purposes in biomedicine, catalysis, and materials science. We describe here the simultaneous modification of the bacteriophage Qβ VLP with a metalloporphyrin derivative for photodynamic therapy and a glycan ligand for specific targeting of cells bearing the CD22 receptor. This application benefits from the presence of the targeting function and the delivery of a high local concentration of singlet oxygen-generating payload.

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Glycan-targeted virus-like nanoparticles for photodynamic therapy

Abstract

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