Glycan-targeted virus-like nanoparticles for photodynamic therapy

Jin Kyu Rhee, Michael Baksh, Corwin Nycholat, James C. Paulson, Hiroaki Kitagishi, M. G. Finn

Research output: Contribution to journalArticlepeer-review

80 Scopus citations

Abstract

Virus-like particles (VLPs) have proven to be versatile platforms for chemical and genetic functionalization for a variety of purposes in biomedicine, catalysis, and materials science. We describe here the simultaneous modification of the bacteriophage Qβ VLP with a metalloporphyrin derivative for photodynamic therapy and a glycan ligand for specific targeting of cells bearing the CD22 receptor. This application benefits from the presence of the targeting function and the delivery of a high local concentration of singlet oxygen-generating payload.

Original languageEnglish
Pages (from-to)2333-2338
Number of pages6
JournalBiomacromolecules
Volume13
Issue number8
DOIs
StatePublished - 13 Aug 2012

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