Glutamate Signaling in Hepatic Stellate Cells Drives Alcoholic Steatosis

Won Mook Choi, Hee Hoon Kim, Myung Ho Kim, Resat Cinar, Hyon Seung Yi, Hyuk Soo Eun, Seok Hwan Kim, Young Jae Choi, Young Sun Lee, So Yeon Kim, Wonhyo Seo, Jun Hee Lee, Young Ri Shim, Ye Eun Kim, Keungmo Yang, Tom Ryu, Jung Hwan Hwang, Chul Ho Lee, Hueng Sik Choi, Bin GaoWon Kim, Sang Kyum Kim, George Kunos, Won Il Jeong

Research output: Contribution to journalArticlepeer-review

62 Scopus citations


Choi et al. show that chronic alcohol consumption induces CYP2E1-mediated reactive oxygen species (ROS) production by hepatocytes, which is compensated by GSH generation through xCT-mediated uptake of cystine. The parallel release of glutamate stimulates mGluR5 on hepatic stellate cells (HSCs) to produce 2-AG, which, in turn, activates CB1R on neighboring hepatocytes to induce de novo lipogenesis.

Original languageEnglish
Pages (from-to)877-889.e7
JournalCell Metabolism
Issue number5
StatePublished - 5 Nov 2019

Bibliographical note

Publisher Copyright:
© 2019 Elsevier Inc.


  • 2-arachidonoylglycerol
  • Nrf2
  • alcoholic liver disease
  • cannabinoid receptor
  • metabotrophic glutamate receptor 5
  • transsulfuration pathway
  • xCT


Dive into the research topics of 'Glutamate Signaling in Hepatic Stellate Cells Drives Alcoholic Steatosis'. Together they form a unique fingerprint.

Cite this