Abstract
Choi et al. show that chronic alcohol consumption induces CYP2E1-mediated reactive oxygen species (ROS) production by hepatocytes, which is compensated by GSH generation through xCT-mediated uptake of cystine. The parallel release of glutamate stimulates mGluR5 on hepatic stellate cells (HSCs) to produce 2-AG, which, in turn, activates CB1R on neighboring hepatocytes to induce de novo lipogenesis.
Original language | English |
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Pages (from-to) | 877-889.e7 |
Journal | Cell Metabolism |
Volume | 30 |
Issue number | 5 |
DOIs | |
State | Published - 5 Nov 2019 |
Bibliographical note
Publisher Copyright:© 2019 Elsevier Inc.
Keywords
- 2-arachidonoylglycerol
- Nrf2
- alcoholic liver disease
- cannabinoid receptor
- metabotrophic glutamate receptor 5
- transsulfuration pathway
- xCT