Glucose metabolism of visceral adipose tissue measured by 18F-FDG PET/CT is related to the presence of colonic adenoma

Hai Jeon Yoon, Bom Sahn Kim, Ko Eun Lee, Chang Mo Moon, Jang Yoo, Jung Sook Kim, Yemi Kim, Michael Masoomi

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4 Scopus citations

Abstract

This study investigated the relationships between the area and metabolic activity of adipose tissue and the presence of colorectal adenoma (CRA). Our institutional review board approved the study and waived informed consent. A total of 212 subjects who underwent fluorine 18 fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) and colonoscopy for routine health check-ups were enrolled. The volumetric parameters of areas of visceral (VATav), subcutaneous (SATav), and total adipose tissue (TATav) and calculated visceral-to-subcutaneous adipose tissue ratio (VSR) and visceral-to-total adipose tissue ratio (VAR) were considered. Metabolic parameters of standardized uptake value (SUV) of visceral (vcSUVmax, vcSUVmean), subcutaneous (scSUVmax, scSUVmean), and calculated visceral-to-subcutaneous adipose tissue ratio (VSRmax, VSRmean) were considered. Anthropometric data of height, weight, body mass index (BMI), waist circumference (WC), body fat mass (BFM), skeletal muscle mass (SMM), and diverse laboratory data were also considered as variables. Sixty-six subjects were placed in the CRA group and 146 subjects in the non-CRA group. The presence of CRA was significantly correlated with older age (P=.001), male sex (P=.041), higher BMI (P=.004), higher WC (P=.001), higher BFM (P=.024), higher VATav (P<.001), higher TATav (P=.004), higher VSR (P<.001), higher VAR (P<.001), lower vcSUVmax (P=.002), lower vcSUVmean (P<.001), and lower VSRmean (P=.002). On multiple regression analysis, vcSUVmax and vcSUVmean were independently associated with the presence of CRA (P=.009 and P=.045). Lower glucose metabolism of visceral adipose tissue was related to the presence of CRA. Our findings identify the value of visceral metabolic dysfunction as a potential surrogate marker of elevated risk for CRA.

Original languageEnglish
Article numbere7156
JournalMedicine (United States)
Volume96
Issue number25
DOIs
StatePublished - 1 Jun 2017

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation (NRF) funded by the Ministry of Education (NRF-2015R1C1A2A01054113 to Hai-Jeon Yoon; NRF-2015R1C1A1A02037051 and NRF-2012M3A9B6055379 to Bom Sahn Kim; and NRF-2014R1A1A2058325 to Chang Mo Moon).

Publisher Copyright:
© 2017 the Author(s).

Keywords

  • Colonic adenoma
  • Fluorodeoxyglucose positron emission tomography/computed tomography
  • Glucose metabolism
  • Visceral adipose tissue

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