TY - JOUR
T1 - Glucose metabolism of visceral adipose tissue measured by 18F-FDG PET/CT is related to the presence of colonic adenoma
AU - Yoon, Hai Jeon
AU - Kim, Bom Sahn
AU - Lee, Ko Eun
AU - Moon, Chang Mo
AU - Yoo, Jang
AU - Kim, Jung Sook
AU - Kim, Yemi
AU - Masoomi, Michael
N1 - Publisher Copyright:
© 2017 the Author(s).
PY - 2017/6/1
Y1 - 2017/6/1
N2 - This study investigated the relationships between the area and metabolic activity of adipose tissue and the presence of colorectal adenoma (CRA). Our institutional review board approved the study and waived informed consent. A total of 212 subjects who underwent fluorine 18 fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) and colonoscopy for routine health check-ups were enrolled. The volumetric parameters of areas of visceral (VATav), subcutaneous (SATav), and total adipose tissue (TATav) and calculated visceral-to-subcutaneous adipose tissue ratio (VSR) and visceral-to-total adipose tissue ratio (VAR) were considered. Metabolic parameters of standardized uptake value (SUV) of visceral (vcSUVmax, vcSUVmean), subcutaneous (scSUVmax, scSUVmean), and calculated visceral-to-subcutaneous adipose tissue ratio (VSRmax, VSRmean) were considered. Anthropometric data of height, weight, body mass index (BMI), waist circumference (WC), body fat mass (BFM), skeletal muscle mass (SMM), and diverse laboratory data were also considered as variables. Sixty-six subjects were placed in the CRA group and 146 subjects in the non-CRA group. The presence of CRA was significantly correlated with older age (P=.001), male sex (P=.041), higher BMI (P=.004), higher WC (P=.001), higher BFM (P=.024), higher VATav (P<.001), higher TATav (P=.004), higher VSR (P<.001), higher VAR (P<.001), lower vcSUVmax (P=.002), lower vcSUVmean (P<.001), and lower VSRmean (P=.002). On multiple regression analysis, vcSUVmax and vcSUVmean were independently associated with the presence of CRA (P=.009 and P=.045). Lower glucose metabolism of visceral adipose tissue was related to the presence of CRA. Our findings identify the value of visceral metabolic dysfunction as a potential surrogate marker of elevated risk for CRA.
AB - This study investigated the relationships between the area and metabolic activity of adipose tissue and the presence of colorectal adenoma (CRA). Our institutional review board approved the study and waived informed consent. A total of 212 subjects who underwent fluorine 18 fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) and colonoscopy for routine health check-ups were enrolled. The volumetric parameters of areas of visceral (VATav), subcutaneous (SATav), and total adipose tissue (TATav) and calculated visceral-to-subcutaneous adipose tissue ratio (VSR) and visceral-to-total adipose tissue ratio (VAR) were considered. Metabolic parameters of standardized uptake value (SUV) of visceral (vcSUVmax, vcSUVmean), subcutaneous (scSUVmax, scSUVmean), and calculated visceral-to-subcutaneous adipose tissue ratio (VSRmax, VSRmean) were considered. Anthropometric data of height, weight, body mass index (BMI), waist circumference (WC), body fat mass (BFM), skeletal muscle mass (SMM), and diverse laboratory data were also considered as variables. Sixty-six subjects were placed in the CRA group and 146 subjects in the non-CRA group. The presence of CRA was significantly correlated with older age (P=.001), male sex (P=.041), higher BMI (P=.004), higher WC (P=.001), higher BFM (P=.024), higher VATav (P<.001), higher TATav (P=.004), higher VSR (P<.001), higher VAR (P<.001), lower vcSUVmax (P=.002), lower vcSUVmean (P<.001), and lower VSRmean (P=.002). On multiple regression analysis, vcSUVmax and vcSUVmean were independently associated with the presence of CRA (P=.009 and P=.045). Lower glucose metabolism of visceral adipose tissue was related to the presence of CRA. Our findings identify the value of visceral metabolic dysfunction as a potential surrogate marker of elevated risk for CRA.
KW - Colonic adenoma
KW - Fluorodeoxyglucose positron emission tomography/computed tomography
KW - Glucose metabolism
KW - Visceral adipose tissue
UR - http://www.scopus.com/inward/record.url?scp=85021764298&partnerID=8YFLogxK
U2 - 10.1097/MD.0000000000007156
DO - 10.1097/MD.0000000000007156
M3 - Article
C2 - 28640092
AN - SCOPUS:85021764298
SN - 0025-7974
VL - 96
JO - Medicine (United States)
JF - Medicine (United States)
IS - 25
M1 - e7156
ER -