Glomerular Filtration Rates in Asians

Boon Wee Teo, Luxia Zhang, Jinn Yuh Guh, Sydney C.W. Tang, Vivekanand Jha, Duk Hee Kang, Roberto Tanchanco, Lai Seong Hooi, Kearkiat Praditpornsilpa, Xianglei Kong, Li Zuo, Gek Cher Chan, Evan J.C. Lee

Research output: Contribution to journalReview articlepeer-review

40 Scopus citations


The National Kidney Foundation Kidney Disease Outcomes Quality Initiative guidelines recommended the Modification of Diet in Renal Disease study equation for estimating glomerular filtration rate (GFR) for the classification of CKD, but its accuracy was limited to North American patients with estimated GFR <60 mL/min per 1.73 m2 body surface area of European (White) or African (Black) descent. The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) developed another equation for estimating GFR, derived from a population that included both participants without kidney disease and with CKD. But many ethnicities were inadequately represented. The International Society of Nephrology, Kidney Disease Improving Global Outcomes committee promulgated clinical practice guidelines, which recommended the CKD-EPI equation. Investigators in Asia subsequently assessed the performance of these GFR estimating equations—the Modification of Diet in Renal Disease study equation, the CKD-EPI equation (creatinine only), and the CKD-EPI equations (creatinine and cystatin C). In this review, we summarize the studies performed in Asia on validating or establishing new Asian ethnicity GFR estimating equations. We included both prospective and retrospective studies which used serum markers traceable to reference materials and focused the review of the performance of GFR estimation by comparisons with the GFR estimations obtained from the CKD-EPI equations.

Original languageEnglish
Pages (from-to)41-48
Number of pages8
JournalAdvances in Chronic Kidney Disease
Issue number1
StatePublished - Jan 2018

Bibliographical note

Publisher Copyright:
© 2017 National Kidney Foundation, Inc.


  • Asian
  • Chronic kidney failure
  • Creatinine
  • Cystatin C
  • Glomerular filtration rate


Dive into the research topics of 'Glomerular Filtration Rates in Asians'. Together they form a unique fingerprint.

Cite this