Global physiological understanding and metabolic engineering of microorganisms based on omics studies

S. J. Park, S. Y. Lee, J. Cho, T. Y. Kim, J. W. Lee, J. H. Park, M. J. Han

Research output: Contribution to journalShort surveypeer-review

59 Scopus citations

Abstract

Through metabolic engineering, scientists seek to modify the metabolic pathways of living organisms to facilitate optimized, efficient production of target biomolecules. During the past decade, we have seen notable improvements in biotechnology, many of which have been based on metabolically engineered microorganisms. Recent developments in the fields of functional genomics, transcriptomics, proteomics, and metabolomics have changed metabolic engineering strategies from the local pathway level to the whole system level. This article focuses on recent advances in the field of metabolic engineering, which have been powered by the combined approaches of the various "omics" that allow us to understand the microbial metabolism at a global scale and to develop more effectively redesigned metabolic pathways for the enhanced production of target bioproducts.

Original languageEnglish
Pages (from-to)567-579
Number of pages13
JournalApplied Microbiology and Biotechnology
Volume68
Issue number5
DOIs
StatePublished - Sep 2005

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