Ginseng saponin metabolite induces apoptosis in MCF-7 breast cancer cells through the modulation of AMP-activated protein kinase

Areum Daseul Kim, Kyoung Ah Kang, Rui Zhang, Chae Moon Lim, Hee Sun Kim, Dong Hyun Kim, You Jin Jeon, Chang Hyun Lee, Jinny Park, Weon Young Chang, Jin Won Hyun

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

Previous studies have shown that the ginseng saponin metabolite, Compound K (20-O-d-glucopyranosyl-20(S)-protopanaxadiol, IH901), suppresses proliferation of various cancers and induces apoptosis. AMP-activated protein kinase (AMPK) is a sensor of cellular energy states and is involved in apoptosis of cancer cells. We hypothesized that Compound K may exert cytotoxicity in MCF-7 human breast cancer cells through modulation of AMPK, followed by a decrease in cyclooxygenase-2 (COX-2) expression. Compound K inhibited cell growth, induced apoptosis via generation of reactive oxygen species (ROS), as well as decreasing COX-2 expression and prostaglandin E2 (PGE2) levels. These effects of Compound K were induced via an AMPK-dependent pathway and were abrogated by a specific AMPK inhibitor. These results suggest that Compound K induced apoptosis by modulating AMPK-COX-2 signaling in MCF-7 human breast cancer cells.

Original languageEnglish
Pages (from-to)134-140
Number of pages7
JournalEnvironmental Toxicology and Pharmacology
Volume30
Issue number2
DOIs
StatePublished - Sep 2010

Keywords

  • AMP-activated protein kinase
  • Apoptosis
  • Compound K
  • MCF-7
  • Reactive oxygen species

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