Ginkgo biloba extract (GbE) enhances the anti-atherogenic effect of cilostazol by inhibiting ROS generation

In Hyuk Jung, You Han Lee, Ji Young Yoo, Se Jin Jeong, Seong Keun Sonn, Jong Gil Park, Keun Ho Ryu, Bong Yong Lee, Hye Young Han, So Young Lee, Dae Yong Kim, Hang Lee, Goo Taeg Oh

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


In this study, the synergistic effect of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl) butoxy]-3,4-dihydro-2(1H)-quinolinone (cilostazol) and Ginkgo biloba extract (GbE) was examined in apolipoprotein E (ApoE) null mice. Co-treatment with GbE and cilostazol synergistically decreased reactive oxygen species (ROS) production in ApoE null mice fed a high-fat diet. Co-treatment resulted in a significantly decreased atherosclerotic lesion area compared to untreated ApoE mice. The inflammatory cytokines and adhesion molecules such as monocyte chemoattractant-1 (MCP-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), and VCAM-1 which can initiate atherosclerosis were significantly reduced by the co-treatment of cilostazol with GbE. Further, the infiltration of macrophages into the intima was decreased by co-treatment. These results suggest that co-treatment of GbE with cilostazol has a more potent anti-atherosclerotic effect than treatment with cilostazol alone in hyperlipidemic ApoE null mice and could be a valuable therapeutic strategy for the treatment of atherosclerosis.

Original languageEnglish
Pages (from-to)311-318
Number of pages8
JournalExperimental and Molecular Medicine
Issue number5
StatePublished - 2012


  • Animal
  • Atherosclerosis
  • Cilostazol
  • Cytokines
  • Disease models
  • Ginkgo biloba
  • Inflammation
  • Macrophages
  • Reactive oxygen species


Dive into the research topics of 'Ginkgo biloba extract (GbE) enhances the anti-atherogenic effect of cilostazol by inhibiting ROS generation'. Together they form a unique fingerprint.

Cite this