Genetic susceptibility of term pregnant women to oxidative damage

Yun Chul Hong, Kwan Hee Lee, Cheol Ho Yi, Eun Hee Ha, David C. Christiani

Research output: Contribution to journalArticlepeer-review

58 Scopus citations

Abstract

Genetic polymorphisms involved in the activation and detoxification of exogenous chemicals and in the production and scavenging of reactive oxygen species may modulate the levels of oxidative injury biomarker. We investigated 81 pregnant women in Inchon, Korea. In addition to a questionnaire survey, urinary concentrations of 8-hydroxydeoxyguanosine (8-OH-dG) and malondialdehyde (MDA) were measured as oxidative injury biomarkers. Cytochrome P-450(CYP)1A1, CYP2E1, glutathione S-transferase (GST)M1 and GSTT1 polymorphisms and myeloperoxidase (MPO) and manganese superoxide dismutase (MnSOD) polymorphisms were evaluated to determine the effect of genetic modification on urinary 8-OH-dG and MDA. The concentrations of urinary 8-OH-dG were significantly elevated in the presence of the MnSOD variant genotype (P=0.04) and in the case of GSTM1 null status (P=0.02) by multivariate regression. The concentrations of urinary MDA were not affected significantly by the genetic polymorphisms. This result shows that oxidative stress injury is modified by some heritable polymorphisms, including GSTM1 and MnSOD.

Original languageEnglish
Pages (from-to)255-262
Number of pages8
JournalToxicology Letters
Volume129
Issue number3
DOIs
StatePublished - 28 Mar 2002

Keywords

  • Genetic susceptibility
  • Oxidative damage
  • Pregnancy

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