Abstract
We examined whether common single nucleotide polymorphisms (SNP) in SULT1A1 (c.779G>A, *14A>G, and *85C>T) and SULT1E1 (IVS1-447C>A, IVS4-1653T>C, and *959G>A) genes influenced the risk and survival of breast cancer. Our study population consisted of 989 histologically confirmed sporadic breast cancer patients and 1,054 controls without history of cancer recruited from three teaching hospitals in Seoul. Odds ratios (OR) and 95% confidence intervals (95% CI) were estimated by logistic regression model. In the survival analysis for 529 breast cancer patients with completed treatments, the hazard ratios (HR) were calculated with Cox proportional hazard model. Women with the SULT1E1 *959 GA/AA genotype had a moderately decreased breast cancer risk compared with those with the GG genotypes (OR, 0.8; 95% CI, 0.70-1.00). When the haplotypes were considered, the homozygous *959 AA genotype together with the IVS4-1653 T>C base change (CTA-CCA haplotype) was associated with halved breast cancer risk (OR, 0.5; 95% CI, 0.24-0.88) compared with the wild type CTG-CTG haplotype. No other significant overall association was observed between the SULT1A1 and SULT1E1 SNPs nor haplotypes and breast cancer risk. When stratified by survival, patients with the SULT1E1 IVS4-1653 TC/CC genotypes showed a >3-fold risk of recurrence (HR, 3.2; 95% CI, 1.39-7.48) compared with those with the TT genotype. Moreover, when the haplotypes were considered, the SULT1E1 *959 G>A base change together with the IVS4-1653 T>C base change (CTG-CCA haplotype) was associated with a >4-fold risk of breast cancer (OR, 4.2; 95% CI, 1.15-15.15). These findings suggest that genetic polymorphisms of SULT1E1 are associated with increased risk and a disease free survival of breast cancer in Korean women.
| Original language | English |
|---|---|
| Pages (from-to) | 1090-1095 |
| Number of pages | 6 |
| Journal | Cancer Epidemiology Biomarkers and Prevention |
| Volume | 14 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 2005 |
Bibliographical note
Funding Information:This work was financially supported by: Project POCI-01-0145-FEDER-006984 ? Associate Laboratory LSRE-LCM funded by FEDER funds through COMPETE2020 ? Programa Operacional Competitividade e Internacionaliza??o (POCI) ? and by national funds through FCT ? Funda??o para a Ci?ncia e a Tecnologia, and by QREN, ON2 and FEDER (NORTE-07-0124-FEDER-000015, NORTE-07-0124-FEDER-000013, NORTE-07-0162-FEDER-000050). FCT is acknowledged for the research grant PD/BD/52623/2014 (MJL). AMTS and CGS acknowledge the FCT Investigator Programme (IF/01501/2013 and IF/00514/2014, respectively) with financing from the European Social Fund and the Human Potential Operational Programme. The authors acknowledge Dr. V.J.P. Vilar for providing the lab-scale CPC. We are indebted to Dr. Carlos S? and the CEMUP team (Portugal) for technical assistance and advice with XPS and SEM/EDXS measurements. We also thank Prof. Pedro B. Tavares (UTAD, Portugal) for the assistance with XRD analysis.