Genetic polymorphisms of CASR and cancer risk: Evidence from meta-analysis and HuGe review

Sohyun Jeong, Jae Hyun Kim, Myeong Gye Kim, Nayoung Han, In Wha Kim, Therasa Kim, Jung Mi Oh

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Background: CASR gene appears to be involved in cancer biology and physiology. However, a number of studies investigating CASR polymorphisms and cancer risks have presented inconclusive results. Thus, a systematic review and a meta-analysis of the effect of CASR polymorphisms on several cancer risks were performed to suggest a statistical evidence for the association of CASR polymorphisms with cancer risks. Methods: MEDLINE, EMBASE, Web of Science, Scopus, and the HuGE databases were searched. Nineteen articles of case–control and cohort studies were included for the final analysis. Results: The colorectal cancer risk was reduced in proximal (odds ratio [OR] =0.679, P=0.001) and distal (OR =0.753, P=0.026) colon sites with GG genotype of CASR rs1042636 and increased in distal colon site (OR =1.418, P=0.039) with GG genotype of rs1801726 by additive genetic model. The rs17251221 demonstrated noticeable associations that carrying a homozygote variant increases breast and prostate cancer risk considerably. Conclusion: The significant association of CASR polymorphisms with several cancer risks was observed in this review. In particular, the act of CASR polymorphisms as a tumor suppressor or an oncogene differs by cancer site and can be the research target for tumorigenesis.

Original languageEnglish
Pages (from-to)655-669
Number of pages15
JournalOncoTargets and Therapy
StatePublished - 9 Feb 2016

Bibliographical note

Publisher Copyright:
© 2016 Jeong et al.


  • Colorectal cancer
  • Rs1042636
  • Rs1801725
  • Rs1801726
  • Systematic review


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