Genetic polymorphisms in peroxisome proliferator-activated receptor γ are associated with Type 2 diabetes mellitus and obesity in the Korean population

M. K. Moon, Y. M. Cho, H. S. Jung, Y. J. Park, K. H. Yoon, Y. A. Sung, B. L. Park, H. K. Lee, Kyong Soo Park, H. D. Shin

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38 Scopus citations

Abstract

Aims: We examined whether the common polymorphisms of the peroxisome proliferator-activated receptor-γ (PPARγ) gene are associated with Type 2 diabetes or obesity in the Korean population. Methods: We genotyped two common PPARγ polymorphisms (Pro12Ala and 161C > T) and examined their association with the clinical phenotypes found in 684 patients with Type 2 diabetes mellitus and 291 non-diabetic control subjects. Results: The 12Ala allele was less frequent in the Type 2 diabetic patients than in the non-diabetic control subjects (0.036 vs. 0.053, P = 0.024). The allele frequencies of the 161C > T polymorphism did not differ between the control and Type 2 diabetic group (0.158 vs. 0.173). In the non-diabetic controls, those with the T allele had lower BMI and fasting serum triglyceride (TG) concentrations than those with the C/C homozygote (22.712.9 vs. 23.8 ± 3.2 kg/m2, P = 0.002; 1.45 ± 0.81 vs. 1.65 ± 0.83 mmol/1, P = 0.03, respectively). The 12Ala-161T haplotype was associated with a decreased risk for Type 2 diabetes (OR = 0.47, P = 0.009), whereas the 12Pro-161T haplotype was associated with lower BMI and lower fasting serum TG (22.5 ± 2.8 vs. 23.7 ± 3.2 kg/m2, P = 0.004; 1.41 ± 0.87 vs. 1.64 ± 0.79 mmol/1, P = 0.02, respectively). Conclusions: The PPARγ 12Ala allele was associated with a reduced risk of Type 2 diabetes, whereas the PPARγ 161T allele was associated with lower BMI and fasting serum TG concentrations in the Korean subjects. The subjects with 12Ala-161T haplotypes had a reduced risk of Type 2 diabetes.

Original languageEnglish
Pages (from-to)1161-1166
Number of pages6
JournalDiabetic Medicine
Volume22
Issue number9
DOIs
StatePublished - Sep 2005

Keywords

  • Korean
  • Obesity
  • Peroxisome proliferator-activated receptor γ
  • Polymorphism
  • Type 2 diabetes

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