Genetic Influences on the Developing Young Brain and Risk for Neuropsychiatric Disorders

for the ENIGMA ORIGINs group

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

Imaging genetics provides an opportunity to discern associations between genetic variants and brain imaging phenotypes. Historically, the field has focused on adults and adolescents; very few imaging genetics studies have focused on brain development in infancy and early childhood (from birth to age 6 years). This is an important knowledge gap because developmental changes in the brain during the prenatal and early postnatal period are regulated by dynamic gene expression patterns that likely play an important role in establishing an individual's risk for later psychiatric illness and neurodevelopmental disabilities. In this review, we summarize findings from imaging genetics studies spanning from early infancy to early childhood, with a focus on studies examining genetic risk for neuropsychiatric disorders. We also introduce the Organization for Imaging Genomics in Infancy (ORIGINs), a working group of the ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) consortium, which was established to facilitate large-scale imaging genetics studies in infancy and early childhood.

Original languageEnglish
Pages (from-to)905-920
Number of pages16
JournalBiological Psychiatry
Volume93
Issue number10
DOIs
StatePublished - 15 May 2023

Bibliographical note

Publisher Copyright:
© 2023 Society of Biological Psychiatry

Keywords

  • Childhood
  • Genetics
  • Imaging
  • Infant
  • Magnetic resonance imaging
  • Pediatric

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