Genetic association of DRD2 polymorphisms with anxiety scores among alcohol-dependent patients

Keun Ho Joe; Dai Jin Kim; Byung Lae Park; Sujung Yoon; Hae Kook Lee; Tae Suk Kim; Young Hoon Cheon; Do Hoon Gwon; Sung Nam Cho; Hye Won Lee; Suk NamGung; Hyoung Doo Shin

doi:10.1016/j.bbrc.2008.02.076

Genetic association of DRD2 polymorphisms with anxiety scores among alcohol-dependent patients

Keun Ho Joe, Dai Jin Kim, Byung Lae Park, Sujung Yoon, Hae Kook Lee, Tae Suk Kim, Young Hoon Cheon, Do Hoon Gwon, Sung Nam Cho, Hye Won Lee, Suk NamGung, Hyoung Doo Shin

Ewha Brain Institute

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

The dopaminergic neurotransmission system is one of the major factors in development of alcoholism and also contributes to anxiety and depression. In this study, the associations of the dopamine receptor type 2 (DRD2) polymorphisms with the symptoms of anxiety were analyzed. A total of 573 alcoholics and 273 controls were enrolled in the study from the Korean population. Five DRD2 SNPs, including -32869 A>G, -32768 insdel C, +11890 C>G, +11915 C>T, and +32806 C>T, were genotyped using a TaqMan assay and analyzed with various alcoholic phenotypes. Although no DRD2 polymorphisms were associated with the risk of alcoholism, +32806 C>T and Block2-ht1 showed associations (in dominant models) with both the state anxiety level scale (STAI-S) and the trait anxiety level scale (STAI-T) (P = 0.004 and P = 0.003, and P = 0.01 and P = 0.005, respectively). In addition, the -32768 insdel C also showed positive association with both anxiety level scales in recessive models (P = 0.01 and P = 0.02, respectively).

Original language	English
Pages (from-to)	591-595
Number of pages	5
Journal	Biochemical and Biophysical Research Communications
Volume	371
Issue number	4
DOIs	https://doi.org/10.1016/j.bbrc.2008.02.076
State	Published - 11 Jul 2008

Bibliographical note

Funding Information:
This study was supported by a grant from the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea (03-PJ10-PG13-GD01-0002), and a grant from the Biomedical Brain Research Center of the Korea Health 21 R&D Project funded by the Ministry of Health & Welfare, Republic of Korea. (A040042). Financial support was also provided by the Catholic Medical Center Research Foundation in the program year of 2006.

Keywords

Alcoholism
DRD2
Polymorphism
STAI-S
STAI-T

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title = "Genetic association of DRD2 polymorphisms with anxiety scores among alcohol-dependent patients",

abstract = "The dopaminergic neurotransmission system is one of the major factors in development of alcoholism and also contributes to anxiety and depression. In this study, the associations of the dopamine receptor type 2 (DRD2) polymorphisms with the symptoms of anxiety were analyzed. A total of 573 alcoholics and 273 controls were enrolled in the study from the Korean population. Five DRD2 SNPs, including -32869 A>G, -32768 insdel C, +11890 C>G, +11915 C>T, and +32806 C>T, were genotyped using a TaqMan assay and analyzed with various alcoholic phenotypes. Although no DRD2 polymorphisms were associated with the risk of alcoholism, +32806 C>T and Block2-ht1 showed associations (in dominant models) with both the state anxiety level scale (STAI-S) and the trait anxiety level scale (STAI-T) (P = 0.004 and P = 0.003, and P = 0.01 and P = 0.005, respectively). In addition, the -32768 insdel C also showed positive association with both anxiety level scales in recessive models (P = 0.01 and P = 0.02, respectively).",

keywords = "Alcoholism, DRD2, Polymorphism, STAI-S, STAI-T",

author = "Joe, {Keun Ho} and Kim, {Dai Jin} and Park, {Byung Lae} and Sujung Yoon and Lee, {Hae Kook} and Kim, {Tae Suk} and Cheon, {Young Hoon} and Gwon, {Do Hoon} and Cho, {Sung Nam} and Lee, {Hye Won} and Suk NamGung and Shin, {Hyoung Doo}",

note = "Funding Information: This study was supported by a grant from the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea (03-PJ10-PG13-GD01-0002), and a grant from the Biomedical Brain Research Center of the Korea Health 21 R&D Project funded by the Ministry of Health & Welfare, Republic of Korea. (A040042). Financial support was also provided by the Catholic Medical Center Research Foundation in the program year of 2006. ",

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AU - Joe, Keun Ho

AU - Kim, Dai Jin

AU - Park, Byung Lae

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AU - Lee, Hae Kook

AU - Kim, Tae Suk

AU - Cheon, Young Hoon

AU - Gwon, Do Hoon

AU - Cho, Sung Nam

AU - Lee, Hye Won

AU - NamGung, Suk

AU - Shin, Hyoung Doo

N1 - Funding Information: This study was supported by a grant from the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea (03-PJ10-PG13-GD01-0002), and a grant from the Biomedical Brain Research Center of the Korea Health 21 R&D Project funded by the Ministry of Health & Welfare, Republic of Korea. (A040042). Financial support was also provided by the Catholic Medical Center Research Foundation in the program year of 2006.

PY - 2008/7/11

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N2 - The dopaminergic neurotransmission system is one of the major factors in development of alcoholism and also contributes to anxiety and depression. In this study, the associations of the dopamine receptor type 2 (DRD2) polymorphisms with the symptoms of anxiety were analyzed. A total of 573 alcoholics and 273 controls were enrolled in the study from the Korean population. Five DRD2 SNPs, including -32869 A>G, -32768 insdel C, +11890 C>G, +11915 C>T, and +32806 C>T, were genotyped using a TaqMan assay and analyzed with various alcoholic phenotypes. Although no DRD2 polymorphisms were associated with the risk of alcoholism, +32806 C>T and Block2-ht1 showed associations (in dominant models) with both the state anxiety level scale (STAI-S) and the trait anxiety level scale (STAI-T) (P = 0.004 and P = 0.003, and P = 0.01 and P = 0.005, respectively). In addition, the -32768 insdel C also showed positive association with both anxiety level scales in recessive models (P = 0.01 and P = 0.02, respectively).

AB - The dopaminergic neurotransmission system is one of the major factors in development of alcoholism and also contributes to anxiety and depression. In this study, the associations of the dopamine receptor type 2 (DRD2) polymorphisms with the symptoms of anxiety were analyzed. A total of 573 alcoholics and 273 controls were enrolled in the study from the Korean population. Five DRD2 SNPs, including -32869 A>G, -32768 insdel C, +11890 C>G, +11915 C>T, and +32806 C>T, were genotyped using a TaqMan assay and analyzed with various alcoholic phenotypes. Although no DRD2 polymorphisms were associated with the risk of alcoholism, +32806 C>T and Block2-ht1 showed associations (in dominant models) with both the state anxiety level scale (STAI-S) and the trait anxiety level scale (STAI-T) (P = 0.004 and P = 0.003, and P = 0.01 and P = 0.005, respectively). In addition, the -32768 insdel C also showed positive association with both anxiety level scales in recessive models (P = 0.01 and P = 0.02, respectively).

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ER -

Genetic association of DRD2 polymorphisms with anxiety scores among alcohol-dependent patients

Abstract

Bibliographical note

Keywords

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