Genetic association of DRD2 polymorphisms with anxiety scores among alcohol-dependent patients

Keun Ho Joe, Dai Jin Kim, Byung Lae Park, Sujung Yoon, Hae Kook Lee, Tae Suk Kim, Young Hoon Cheon, Do Hoon Gwon, Sung Nam Cho, Hye Won Lee, Suk NamGung, Hyoung Doo Shin

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18 Scopus citations


The dopaminergic neurotransmission system is one of the major factors in development of alcoholism and also contributes to anxiety and depression. In this study, the associations of the dopamine receptor type 2 (DRD2) polymorphisms with the symptoms of anxiety were analyzed. A total of 573 alcoholics and 273 controls were enrolled in the study from the Korean population. Five DRD2 SNPs, including -32869 A>G, -32768 insdel C, +11890 C>G, +11915 C>T, and +32806 C>T, were genotyped using a TaqMan assay and analyzed with various alcoholic phenotypes. Although no DRD2 polymorphisms were associated with the risk of alcoholism, +32806 C>T and Block2-ht1 showed associations (in dominant models) with both the state anxiety level scale (STAI-S) and the trait anxiety level scale (STAI-T) (P = 0.004 and P = 0.003, and P = 0.01 and P = 0.005, respectively). In addition, the -32768 insdel C also showed positive association with both anxiety level scales in recessive models (P = 0.01 and P = 0.02, respectively).

Original languageEnglish
Pages (from-to)591-595
Number of pages5
JournalBiochemical and Biophysical Research Communications
Issue number4
StatePublished - 11 Jul 2008

Bibliographical note

Funding Information:
This study was supported by a grant from the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea (03-PJ10-PG13-GD01-0002), and a grant from the Biomedical Brain Research Center of the Korea Health 21 R&D Project funded by the Ministry of Health & Welfare, Republic of Korea. (A040042). Financial support was also provided by the Catholic Medical Center Research Foundation in the program year of 2006.


  • Alcoholism
  • DRD2
  • Polymorphism
  • STAI-S
  • STAI-T


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