General and programmable synthesis of hybrid liposome/metal nanoparticles

Jin Ho Lee, Yonghee Shin, Wooju Lee, Keumrai Whang, Dongchoul Kim, Luke P. Lee, Jeong Woo Choi, Taewook Kang

Research output: Contribution to journalArticlepeer-review

56 Scopus citations


Hybrid liposome/metal nanoparticles are promising candidate materials for biomedical applications. However, the poor selectivity and low yield of the desired hybrid during synthesis pose a challenge. We designed a programmable liposome by selective encoding of a reducing agent, which allows self-crystallization of metal nanoparticles within the liposome to produce stable liposome/metal nanoparticles alone. We synthesized seven types of liposome/monometallic and more complex liposome/bimetallic hybrids. The resulting nanoparticles are tunable in size and metal composition, and their surface plasmon resonance bands are controllable in visible and near infrared. Owing to outer lipid bilayer, our liposome/Au nanoparticle shows better colloidal stability in biologically relevant solutions as well as higher endocytosis efficiency than gold nanoparticles without the liposome. We used this hybrid in intracellular imaging of living cells via surface-enhanced Raman spectroscopy, taking advantage of its improved physicochemical properties. We believe that our method greatly increases the utility of metal nanoparticles in in vivo applications.

Original languageEnglish
Article numbere1601838
JournalScience Advances
Issue number12
StatePublished - Dec 2016

Bibliographical note

Funding Information:
This research was supported by the International Research and Development Program of the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT, and Future Planning (MSIP) (no. 2016K1A3A1A32913356), by the Mid-Career Researcher Support Program (no. 2016R1A2B3014157), and by the Leading Foreign Research Institute Recruitment Program through the NRF, funded by MSIP (no. 2013K1A4A3055268).

Publisher Copyright:
© 2016 The Authors.


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