Gender differences in the membrane transport of endogenous and exogenous compounds

Marilyn E. Morris, Hwa Jeong Lee, Lisa M. Predko

Research output: Contribution to journalReview articlepeer-review

114 Scopus citations

Abstract

Gender differences have been well described in pharmacokinetics and contribute to the interindividual variation in drug disposition, therapeutic response, and drug toxicity. Sex-related differences in the membrane transport of endogenous substrates and xenobiotics have been reported in various organs of the body including kidney, liver, intestine, and brain. These gender-related differences in transport systems could also contribute to interindividual variability in pharmacokinetics and pharmacodynamics. This review will focus on current knowledge of gender-associated differences in the transport of endogenous and exogenous compounds in a variety of body organs and will discuss the implications and the clinical significance of these observations.

Original languageEnglish
Pages (from-to)229-240
Number of pages12
JournalPharmacological Reviews
Volume55
Issue number2
DOIs
StatePublished - Jun 2003

Fingerprint

Dive into the research topics of 'Gender differences in the membrane transport of endogenous and exogenous compounds'. Together they form a unique fingerprint.

Cite this