Gender differences in risk factors for transition from mild cognitive impairment to Alzheimer's disease: A CREDOS study

Sangha Kim, Min Ji Kim, Seonwoo Kim, Hyo Shin Kang, Shin Won Lim, Woojae Myung, Yunhwan Lee, Chang Hyung Hong, Seong Hye Choi, Duk L. Na, Sang Won Seo, Bon D. Ku, Seong Yoon Kim, Sang Yun Kim, Jee Hyang Jeong, Sun Ah Park, Bernard J. Carroll, Doh Kwan Kim

Research output: Contribution to journalArticlepeer-review

61 Scopus citations

Abstract

Background Women are subject to a disproportionate burden from Alzheimer's disease (AD) and sex differences exist in treatment response and prognosis of the disease. Yet gender-specific risk factors have not been widely studied. We aimed to investigate gender-specific risk factors for AD in subjects with mild cognitive impairment (MCI). Methods Participants (n = 294) with MCI were recruited from a nationwide, prospective cohort study of dementia and were followed for a median (range) of 13.8 (6.0-36.0) months. Sex-stratified associations of progression to AD with baseline characteristics were explored. Results Seventy-four individuals (25.2%) developed incident dementia (67 AD) during follow-up. Significant risk factors for probable AD differed by sex. In men, the significant risk factors were severe periventricular white matter hyperintensities, and poorer global cognitive function. In women, older age, clinically significant depressive symptoms at baseline, and positive APOE ε4 alleles were the significant risk factors. Conclusions Risk factors for progression from MCI to probable AD differed in men and women. These results may translate to gender-specific preventative or therapeutic strategies for patients with MCI.

Original languageEnglish
Article number51544
Pages (from-to)114-122
Number of pages9
JournalComprehensive Psychiatry
Volume62
DOIs
StatePublished - 1 Oct 2015

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