Gender differences in risk factors for transition from mild cognitive impairment to Alzheimer's disease: A CREDOS study

Sangha Kim; Min Ji Kim; Seonwoo Kim; Hyo Shin Kang; Shin Won Lim; Woojae Myung; Yunhwan Lee; Chang Hyung Hong; Seong Hye Choi; Duk L. Na; Sang Won Seo; Bon D. Ku; Seong Yoon Kim; Sang Yun Kim; Jee Hyang Jeong; Sun Ah Park; Bernard J. Carroll; Doh Kwan Kim

doi:10.1016/j.comppsych.2015.07.002

Gender differences in risk factors for transition from mild cognitive impairment to Alzheimer's disease: A CREDOS study

Sangha Kim, Min Ji Kim, Seonwoo Kim, Hyo Shin Kang, Shin Won Lim, Woojae Myung, Yunhwan Lee, Chang Hyung Hong, Seong Hye Choi, Duk L. Na, Sang Won Seo, Bon D. Ku, Seong Yoon Kim, Sang Yun Kim, Jee Hyang Jeong, Sun Ah Park, Bernard J. Carroll, Doh Kwan Kim

Department of Neurology

Research output: Contribution to journal › Article › peer-review

91 Scopus citations

Abstract

Background Women are subject to a disproportionate burden from Alzheimer's disease (AD) and sex differences exist in treatment response and prognosis of the disease. Yet gender-specific risk factors have not been widely studied. We aimed to investigate gender-specific risk factors for AD in subjects with mild cognitive impairment (MCI). Methods Participants (n = 294) with MCI were recruited from a nationwide, prospective cohort study of dementia and were followed for a median (range) of 13.8 (6.0-36.0) months. Sex-stratified associations of progression to AD with baseline characteristics were explored. Results Seventy-four individuals (25.2%) developed incident dementia (67 AD) during follow-up. Significant risk factors for probable AD differed by sex. In men, the significant risk factors were severe periventricular white matter hyperintensities, and poorer global cognitive function. In women, older age, clinically significant depressive symptoms at baseline, and positive APOE ε4 alleles were the significant risk factors. Conclusions Risk factors for progression from MCI to probable AD differed in men and women. These results may translate to gender-specific preventative or therapeutic strategies for patients with MCI.

Original language	English
Article number	51544
Pages (from-to)	114-122
Number of pages	9
Journal	Comprehensive Psychiatry
Volume	62
DOIs	https://doi.org/10.1016/j.comppsych.2015.07.002
State	Published - 1 Oct 2015

Bibliographical note

Publisher Copyright:
© 2015 Elsevier Inc.

Access to Document

10.1016/j.comppsych.2015.07.002

Cite this

Kim, S., Kim, M. J., Kim, S., Kang, H. S., Lim, S. W., Myung, W., Lee, Y., Hong, C. H., Choi, S. H., Na, D. L., Seo, S. W., Ku, B. D., Kim, S. Y., Kim, S. Y., Jeong, J. H., Park, S. A., Carroll, B. J., & Kim, D. K. (2015). Gender differences in risk factors for transition from mild cognitive impairment to Alzheimer's disease: A CREDOS study. Comprehensive Psychiatry, 62, 114-122. Article 51544. https://doi.org/10.1016/j.comppsych.2015.07.002

@article{fa756a2e69474702bf822af639ab03d3,

title = "Gender differences in risk factors for transition from mild cognitive impairment to Alzheimer's disease: A CREDOS study",

abstract = "Background Women are subject to a disproportionate burden from Alzheimer's disease (AD) and sex differences exist in treatment response and prognosis of the disease. Yet gender-specific risk factors have not been widely studied. We aimed to investigate gender-specific risk factors for AD in subjects with mild cognitive impairment (MCI). Methods Participants (n = 294) with MCI were recruited from a nationwide, prospective cohort study of dementia and were followed for a median (range) of 13.8 (6.0-36.0) months. Sex-stratified associations of progression to AD with baseline characteristics were explored. Results Seventy-four individuals (25.2%) developed incident dementia (67 AD) during follow-up. Significant risk factors for probable AD differed by sex. In men, the significant risk factors were severe periventricular white matter hyperintensities, and poorer global cognitive function. In women, older age, clinically significant depressive symptoms at baseline, and positive APOE ε4 alleles were the significant risk factors. Conclusions Risk factors for progression from MCI to probable AD differed in men and women. These results may translate to gender-specific preventative or therapeutic strategies for patients with MCI.",

author = "Sangha Kim and Kim, {Min Ji} and Seonwoo Kim and Kang, {Hyo Shin} and Lim, {Shin Won} and Woojae Myung and Yunhwan Lee and Hong, {Chang Hyung} and Choi, {Seong Hye} and Na, {Duk L.} and Seo, {Sang Won} and Ku, {Bon D.} and Kim, {Seong Yoon} and Kim, {Sang Yun} and Jeong, {Jee Hyang} and Park, {Sun Ah} and Carroll, {Bernard J.} and Kim, {Doh Kwan}",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier Inc.",

year = "2015",

month = oct,

day = "1",

doi = "10.1016/j.comppsych.2015.07.002",

language = "English",

volume = "62",

pages = "114--122",

journal = "Comprehensive Psychiatry",

issn = "0010-440X",

publisher = "W.B. Saunders Ltd",

}

Kim, S, Kim, MJ, Kim, S, Kang, HS, Lim, SW, Myung, W, Lee, Y, Hong, CH, Choi, SH, Na, DL, Seo, SW, Ku, BD, Kim, SY, Kim, SY, Jeong, JH, Park, SA, Carroll, BJ & Kim, DK 2015, 'Gender differences in risk factors for transition from mild cognitive impairment to Alzheimer's disease: A CREDOS study', Comprehensive Psychiatry, vol. 62, 51544, pp. 114-122. https://doi.org/10.1016/j.comppsych.2015.07.002

TY - JOUR

T1 - Gender differences in risk factors for transition from mild cognitive impairment to Alzheimer's disease

T2 - A CREDOS study

AU - Kim, Sangha

AU - Kim, Min Ji

AU - Kim, Seonwoo

AU - Kang, Hyo Shin

AU - Lim, Shin Won

AU - Myung, Woojae

AU - Lee, Yunhwan

AU - Hong, Chang Hyung

AU - Choi, Seong Hye

AU - Na, Duk L.

AU - Seo, Sang Won

AU - Ku, Bon D.

AU - Kim, Seong Yoon

AU - Kim, Sang Yun

AU - Jeong, Jee Hyang

AU - Park, Sun Ah

AU - Carroll, Bernard J.

AU - Kim, Doh Kwan

PY - 2015/10/1

Y1 - 2015/10/1

N2 - Background Women are subject to a disproportionate burden from Alzheimer's disease (AD) and sex differences exist in treatment response and prognosis of the disease. Yet gender-specific risk factors have not been widely studied. We aimed to investigate gender-specific risk factors for AD in subjects with mild cognitive impairment (MCI). Methods Participants (n = 294) with MCI were recruited from a nationwide, prospective cohort study of dementia and were followed for a median (range) of 13.8 (6.0-36.0) months. Sex-stratified associations of progression to AD with baseline characteristics were explored. Results Seventy-four individuals (25.2%) developed incident dementia (67 AD) during follow-up. Significant risk factors for probable AD differed by sex. In men, the significant risk factors were severe periventricular white matter hyperintensities, and poorer global cognitive function. In women, older age, clinically significant depressive symptoms at baseline, and positive APOE ε4 alleles were the significant risk factors. Conclusions Risk factors for progression from MCI to probable AD differed in men and women. These results may translate to gender-specific preventative or therapeutic strategies for patients with MCI.

AB - Background Women are subject to a disproportionate burden from Alzheimer's disease (AD) and sex differences exist in treatment response and prognosis of the disease. Yet gender-specific risk factors have not been widely studied. We aimed to investigate gender-specific risk factors for AD in subjects with mild cognitive impairment (MCI). Methods Participants (n = 294) with MCI were recruited from a nationwide, prospective cohort study of dementia and were followed for a median (range) of 13.8 (6.0-36.0) months. Sex-stratified associations of progression to AD with baseline characteristics were explored. Results Seventy-four individuals (25.2%) developed incident dementia (67 AD) during follow-up. Significant risk factors for probable AD differed by sex. In men, the significant risk factors were severe periventricular white matter hyperintensities, and poorer global cognitive function. In women, older age, clinically significant depressive symptoms at baseline, and positive APOE ε4 alleles were the significant risk factors. Conclusions Risk factors for progression from MCI to probable AD differed in men and women. These results may translate to gender-specific preventative or therapeutic strategies for patients with MCI.

UR - http://www.scopus.com/inward/record.url?scp=84940662309&partnerID=8YFLogxK

U2 - 10.1016/j.comppsych.2015.07.002

DO - 10.1016/j.comppsych.2015.07.002

M3 - Article

C2 - 26343475

AN - SCOPUS:84940662309

SN - 0010-440X

VL - 62

SP - 114

EP - 122

JO - Comprehensive Psychiatry

JF - Comprehensive Psychiatry

M1 - 51544

ER -

Gender differences in risk factors for transition from mild cognitive impairment to Alzheimer's disease: A CREDOS study

Abstract

Bibliographical note

Access to Document

Fingerprint

Cite this