Furazolidone- and nitrofurantoin-resistant Helicobacter pylori: Prevalence and role of genes involved in metronidazole resistance

D. H. Kwon, M. Lee, J. J. Kim, J. G. Kim, F. A.K. El-Zaatari, M. S. Osato, D. Y. Graham

Research output: Contribution to journalArticlepeer-review

62 Scopus citations

Abstract

The prevalence of furazolidone, nitrofurantoin, and metronidazole resistance among Helicobacter pylori strains was assessed with 431 clinical isolates. Fifty-two percent were metronidazole resistant, compared to 2% (7 of 431) with resistance to furazolidone and nitrofurantoin. All seven furazolidone- and nitrofurantoin-resistant isolates were also metronidazole resistant, rdxA, frxA, and fdxB knockouts did not result in furazolidone or nitrofurantoin resistance. These data suggest that furazolidone and nitrofurantoin may be good alternatives to metronidazole for treating H. pylori infection.

Original languageEnglish
Pages (from-to)306-308
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume45
Issue number1
DOIs
StatePublished - 2001

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