Abstract
Five new furanocoumarins, dahuribirin H (1), dahuribirin I (2), (2′S)-(+)-5-(2′-hydroxy-3′-methylbut-3′-enyloxy)-8-(3′′-methylbut-2″-enyloxy)psoralen (3), (2′R)-(+)-5-(2′,3′-epoxy-3′-methylbutoxy)-8-(3″-methylbut-2″-enyloxy)psoralen (4), and 5-methoxy-8-((Z)-4′-(3″-methylbutanoate)-3′-methylbut-2′-enyloxy)psoralen (5), along with 15 known compounds (6-20), were isolated from the roots of Angelica dahurica. The structures of the new compounds were elucidated by spectroscopic analysis, along with electronic circular dichroism calculations and Mosher ester analysis. Compounds 3, 4, 11, 13, and 16 reduced H2O2-induced cell death in HepG2 cells and attenuated reactive oxygen species (ROS) formation without showing cytotoxicity, suggesting that these compounds might have cytoprotective effects against H2O2-induced oxidative damage via ROS scavenging activities.
Original language | English |
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Pages (from-to) | 2601-2607 |
Number of pages | 7 |
Journal | Journal of Natural Products |
Volume | 82 |
Issue number | 9 |
DOIs | |
State | Published - 27 Sep 2019 |
Bibliographical note
Funding Information:This research was supported by a grant (14272MFDS279) funded by the Ministry of Food and Drug Safety in 2014.*%blankline%*
Publisher Copyright:
Copyright © 2019 American Chemical Society and American Society of Pharmacognosy.