Functional roles of p38 mitogen-activated protein kinase in macrophage-mediated inflammatory responses

Yanyan Yang, Seung Cheol Kim, Tao Yu, Young Su Yi, Man Hee Rhee, Gi Ho Sung, Byong Chul Yoo, Jae Youl Cho

Research output: Contribution to journalReview articlepeer-review

226 Scopus citations

Abstract

Inflammation is a natural host defensive process that is largely regulated by macrophages during the innate immune response. Mitogen-activated protein kinases (MAPKs) are proline-directed serine and threonine protein kinases that regulate many physiological and pathophysiological cell responses. p38 MAPKs are key MAPKs involved in the production of inflammatory mediators, including tumor necrosis factor-α (TNF-α) and cyclooxygenase-2 (COX-2). p38 MAPK signaling plays an essential role in regulating cellular processes, especially inflammation. In this paper, we summarize the characteristics of p38 signaling in macrophage-mediated inflammation. In addition, we discuss the potential of using inhibitors targeting p38 expression in macrophages to treat inflammatory diseases.

Original languageEnglish
Article number352371
JournalMediators of Inflammation
Volume2014
DOIs
StatePublished - 2014

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