Functional regulation of FoxO1 in neural stem cell differentiation

D. Y. Kim; I. Hwang; F. L. Muller; J. H. Paik

doi:10.1038/cdd.2015.123

Functional regulation of FoxO1 in neural stem cell differentiation

D. Y. Kim, I. Hwang, F. L. Muller, J. H. Paik

Department of Pharmaceutical Sciences

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68 Scopus citations

Abstract

Forkhead transcription factor family O (FoxO) maintains adult stem cell reserves by supporting their long-term proliferative potential. MicroRNAs (miRs) regulate neuronal stem/progenitor cell (NSPC) proliferation and differentiation during neural development by controlling the expression of a specific set of target genes. In the neurogenic subventricular zone, FoxO1 is specifically expressed in NSPCs and is no longer detected during the transition to neuroblast stage, forming an inverse correlation with miR-9 expression. The 3′-untranslated region of FoxO1 contains a conserved target sequence of miR-9 and FoxO1 expression is coordinated in concert with miR-9 during neuronal differentiation. Our study demonstrates that FoxO1 contributes to NSPC fate decision through its cooperation with the Notch signaling pathway.

Original language	English
Pages (from-to)	2034-2045
Number of pages	12
Journal	Cell Death and Differentiation
Volume	22
Issue number	12
DOIs	https://doi.org/10.1038/cdd.2015.123
State	Published - 1 Dec 2015

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Functional regulation of FoxO1 in neural stem cell differentiation

Abstract

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