Functional regulation of FoxO1 in neural stem cell differentiation

D. Y. Kim, I. Hwang, F. L. Muller, J. H. Paik

Research output: Contribution to journalArticlepeer-review

67 Scopus citations

Abstract

Forkhead transcription factor family O (FoxO) maintains adult stem cell reserves by supporting their long-term proliferative potential. MicroRNAs (miRs) regulate neuronal stem/progenitor cell (NSPC) proliferation and differentiation during neural development by controlling the expression of a specific set of target genes. In the neurogenic subventricular zone, FoxO1 is specifically expressed in NSPCs and is no longer detected during the transition to neuroblast stage, forming an inverse correlation with miR-9 expression. The 3′-untranslated region of FoxO1 contains a conserved target sequence of miR-9 and FoxO1 expression is coordinated in concert with miR-9 during neuronal differentiation. Our study demonstrates that FoxO1 contributes to NSPC fate decision through its cooperation with the Notch signaling pathway.

Original languageEnglish
Pages (from-to)2034-2045
Number of pages12
JournalCell Death and Differentiation
Volume22
Issue number12
DOIs
StatePublished - 1 Dec 2015

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© 2015 Macmillan Publishers Limited All rights reserved.

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