@article{a5548f74642f45d7a90a314090fe4d37,
title = "Functional and prognostic implications of the main pulmonary artery diameter to aorta diameter ratio from chest computed tomography in Korean COPD patients",
abstract = "Background: The ratio of the diameter of the main pulmonary artery (mPA) to the diameter of the aorta (Ao) on chest computed tomography is associated with diverse clinical conditions. Herein, we determined the functional and prognostic implications of the mPA/Ao ratio in Korean chronic obstructive pulmonary disease (COPD) patients. Methods: The study population comprised 226 chronic obstructive pulmonary disease patients from the Korean Obstructive Lung Disease cohort who underwent chest computed tomography. We analyzed the relationships between the clinical characteristics, including pulmonary function, echocardiography findings, St. George's Respiratory Questionnaire, 6-minute walking (6MW) distance, and exacerbation with the mPA, Ao, and mPA/Ao ratio. Results: The mean age was 65.8 years, and 219 (96.9%) patients were male. The mean FEV1% predicted and FEV1/FVC ratio were 61.2% and 47.3%, respectively. The mean mPA and Ao were 23.7 and 36.4 mm, respectively, and the mPA/Ao ratio was 0.66. The mPA/Ao ratio correlated negatively with the 6MW distance (G = -0.133, P = 0.025) and positively with the right ventricular pressure (G = 0.323, P = 0.001). After adjustment for potential confounders, the mPA/Ao ratio was significantly associated with 6MW distance (β = -107.7, P = 0.017). Moreover, an mPA/Ao ratio >0.8 was a significant predictor of exacerbation at the 1-year (odds ratio 2.12, 95% confidence interval 1.27-3.52) and 3-year follow-ups (odds ratio 2.04, 95% confidence interval 1.42-2.90). Conclusions: The mPA/Ao ratio is an independent predictor of exercise capacity and an mPA/Ao ratio >0.8 is a significant risk factor of COPD exacerbation.",
author = "{Korean Obstructive Lung Disease Study Group} and Chung, {Kyung Soo} and Kim, {Young Sam} and Kim, {Se Kyu} and Kim, {Ha Yan} and Lee, {Sang Min} and Seo, {Joon Beom} and Oh, {Yeon Mok} and Jung, {Ji Ye} and Lee, {Sang Do} and Lee, {Ji Hyun} and Kim, {Eun Kyung} and Kim, {Tae Hyung} and Shin, {Tae Rim} and Yoo, {Kwang Ha} and Sheen, {Seung Soo} and Lee, {Jin Hwa} and Lim, {Seong Yong} and Lee, {Sang Yeub} and Yoon, {Ho Il} and Park, {Yong Bum} and Hwang, {Yong Il} and Yoonki Hong and Ra, {Seung Won} and Lee, {Sei Won} and Lee, {Jae Seung} and Huh, {Jin Won} and Moon, {Ji Yong} and Park, {Hye Kyeong} and Park, {Hye Yun} and Kim, {Jin Woo} and Rhee, {Chin Kook} and Yoon, {Hyoung Kyu} and Kim, {Woo Jin}",
note = "Funding Information: This research was supported by the grant from the Korea Healthcare Technology R&D Project, Ministry of Health and Welfare (HI10C2020 and A102065). All members of the Korean Obstructive Lung Disease (KOLD) Study Group contributed to the recruitment of COPD patients and also to the collection of data and samples: Ji-Hyun Lee, Eun Kyung Kim, Tae-Hyung Kim, Tae Rim Shin, Kwang Ha Yoo, Seung Soo Sheen, Jin Hwa Lee, Seong Yong Lim, Sang Yeub Lee, Ho Il Yoon, Yong Bum Park, Yong Il Hwang, Young Sam Kim, Ji Ye Jung, Yoonki Hong, Seung Won Ra, Joon Beom Seo, Sang Min Lee, Sei Won Lee, Jae Seung Lee, Jin Won Huh, Ji Yong Moon, Hye Kyeong Park, Hye Yun Park, Jin Woo Kim, Chin Kook Rhee, Hyoung Kyu Yoon, Woo Jin Kim, Yeon-Mok Oh, and Sang-Do Lee. Publisher Copyright: {\textcopyright} 2016 Chung et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.",
year = "2016",
month = may,
day = "1",
doi = "10.1371/journal.pone.0154584",
language = "English",
volume = "11",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "5",
}