Functional and morphological ultrasonic biomicroscopy for tissue engineers

S. Mallidi, S. R. Aglyamov, A. B. Karpiouk, S. Park, S. Y. Emelianov

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

16 Scopus citations

Abstract

Tissue engineering is an interdisciplinary field that combines various aspects of engineering and life sciences and aims to develop biological substitutes to restore, repair or maintain tissue function. Currently, the ability to have quantitative functional assays of engineered tissues is limited to existing invasive methods like biopsy. Hence, an imaging tool for non-invasive and simultaneous evaluation of the anatomical and functional properties of the engineered tissue is needed. In this paper we present an advanced in-vivo imaging technology - ultrasound biomicroscopy combined with complementary photoacoustic and elasticity imaging techniques, capable of accurate visualization of both structural and functional changes in engineered tissues, sequential monitoring of tissue adaptation and/or regeneration, and possible assistance of drug delivery and treatment planning. The combined imaging at microscopic resolution was evaluated on tissue mimicking phantoms imaged with 25 MHz single element focused transducer. The results of our study demonstrate that the ultrasonic, photoacoustic and elasticity images synergistically complement each other in detecting features otherwise imperceptible using the individual techniques. Finally, we illustrate the feasibility of the combined ultrasound, photoacoustic and elasticity imaging techniques in accurately assessing the morphological and functional changes occurring in engineered tissue.

Original languageEnglish
Title of host publicationMedical Imaging 2006
Subtitle of host publicationUltrasonic Imaging and Signal Processing
DOIs
StatePublished - 2006
EventMedical Imaging 2006: Ultrasonic Imaging and Signal Processing - San Diego, CA, United States
Duration: 12 Feb 200616 Feb 2006

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6147
ISSN (Print)1605-7422

Conference

ConferenceMedical Imaging 2006: Ultrasonic Imaging and Signal Processing
Country/TerritoryUnited States
CitySan Diego, CA
Period12/02/0616/02/06

Keywords

  • Elasticity imaging
  • Photoacoustic imaging
  • Tissue engineering
  • Ultrasound biomicroscopy

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