Abstract
Fumonisin B1 (FB1) structurally resembles sphingolipids and interferes with their metabolism leading to sphingolipid dysregula-tion. We questioned if FB1 could exacerbate liver or kidney toxicities in glutathione peroxidase 1 (Gpx1) and catalase (Cat) knockout mice. While higher serum levels of thiobarbituric acid reactive substances (TBARS) and sphinganine (Sa) were measured in Gpx1/Cat knockout mice (Gpx1/Cat KO) than wild type mice after 5 days of FB1 treatment, serum levels of alanine aminotrans-ferase (ALT), sphingosine-1 phosphate (So-1-P), and sphinganine-1 phosphate (Sa-1-P) were found to be relatively low. Although Sa was highly elevated in Gpx1/Cat KO mice and wild mice, lower levels of So and Sa were found in both the kidney and liver tissues of Gpx/Cat KO mice than wild type mice after FB1 treatment. Paradoxically, FB1-induced cellular apoptosis and necrosis were hastened under oxidative stress in Gpx1/Cat KO mice.
Original language | English |
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Pages (from-to) | 52-57 |
Number of pages | 6 |
Journal | Biomolecules and Therapeutics |
Volume | 29 |
Issue number | 1 |
DOIs | |
State | Published - 2021 |
Bibliographical note
Funding Information:This research was supported by the National Research Foundation of Korea (NRF) grant funded by the Ministry of
Publisher Copyright:
© 2021 The Korean Society of Applied Pharmacology.
Keywords
- Catalase
- Fumonisin B1
- Glutathione peroxidase1
- Sphinganine
- Sphingosine