Fumonisin b1-induced toxicity was not exacerbated in glutathione peroxidase-1/catalase double knock out mice

Taddesse Yayeh, Ha Ram Jeong, Yoon Soo Park, Sohyeon Moon, Bongjun Sur, Hwan Soo Yoo, Seikwan Oh

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Fumonisin B1 (FB1) structurally resembles sphingolipids and interferes with their metabolism leading to sphingolipid dysregula-tion. We questioned if FB1 could exacerbate liver or kidney toxicities in glutathione peroxidase 1 (Gpx1) and catalase (Cat) knockout mice. While higher serum levels of thiobarbituric acid reactive substances (TBARS) and sphinganine (Sa) were measured in Gpx1/Cat knockout mice (Gpx1/Cat KO) than wild type mice after 5 days of FB1 treatment, serum levels of alanine aminotrans-ferase (ALT), sphingosine-1 phosphate (So-1-P), and sphinganine-1 phosphate (Sa-1-P) were found to be relatively low. Although Sa was highly elevated in Gpx1/Cat KO mice and wild mice, lower levels of So and Sa were found in both the kidney and liver tissues of Gpx/Cat KO mice than wild type mice after FB1 treatment. Paradoxically, FB1-induced cellular apoptosis and necrosis were hastened under oxidative stress in Gpx1/Cat KO mice.

Original languageEnglish
Pages (from-to)52-57
Number of pages6
JournalBiomolecules and Therapeutics
Volume29
Issue number1
DOIs
StatePublished - 2021

Keywords

  • Catalase
  • Fumonisin B1
  • Glutathione peroxidase1
  • Sphinganine
  • Sphingosine

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