Dapsone is a sulfone-type drug used widely for different infectious, immune, and hypersensitivity disorders as an antibacterial treatment alone or in combination for leprosy and sometimes for infected skin lesions. DHS is a severe idiosyncratic adverse reaction with multi-organ involvement. However, acute necrotic hepatitis requiring an emergent LT is rare. Herein, we report a case of 12-yr-old girl who suffered from fulminant hepatitis and multi-organ failure due to DHS for PPD. She was saved by emergent LDLT. A high index of suspicion and rapid diagnosis are necessary not to miss this potentially lethal but rare disease.
Bibliographical notePublisher Copyright:
© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
- Dapsone hypersensitivity syndrome
- Fulminant hepatitis
- Liver transplant
- Pigmented purpuric dermatosis