Fulminant hepatitis linked to dapsone hypersensitivity syndrome requiring urgent living donor liver transplantation: A case report

Angelica Garcia; Nam Joon Yi; Kyoung Bun Lee; Jeong Moo Lee; Young Rok Choi; Suk Won Suh; Tae You; Kwang Woong Lee; June Dong Park; Hyoung Jin Kang; Joon Gon Kim; Eun Kyeong Kang; Geun Hong; Kyung Suk Suh

doi:10.1111/petr.12343

Fulminant hepatitis linked to dapsone hypersensitivity syndrome requiring urgent living donor liver transplantation: A case report

Angelica Garcia, Nam Joon Yi, Kyoung Bun Lee, Jeong Moo Lee, Young Rok Choi, Suk Won Suh, Tae You, Kwang Woong Lee, June Dong Park, Hyoung Jin Kang, Joon Gon Kim, Eun Kyeong Kang, Geun Hong, Kyung Suk Suh

Department of Surgery

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Dapsone is a sulfone-type drug used widely for different infectious, immune, and hypersensitivity disorders as an antibacterial treatment alone or in combination for leprosy and sometimes for infected skin lesions. DHS is a severe idiosyncratic adverse reaction with multi-organ involvement. However, acute necrotic hepatitis requiring an emergent LT is rare. Herein, we report a case of 12-yr-old girl who suffered from fulminant hepatitis and multi-organ failure due to DHS for PPD. She was saved by emergent LDLT. A high index of suspicion and rapid diagnosis are necessary not to miss this potentially lethal but rare disease.

Original language	English
Pages (from-to)	E240-E245
Journal	Pediatric Transplantation
Volume	18
Issue number	7
DOIs	https://doi.org/10.1111/petr.12343
State	Published - 2014

Bibliographical note

Publisher Copyright:
© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Keywords

Dapsone hypersensitivity syndrome
Fulminant hepatitis
Liver transplant
Pigmented purpuric dermatosis

Access to Document

10.1111/petr.12343

Cite this

Garcia, A., Yi, N. J., Lee, K. B., Lee, J. M., Choi, Y. R., Suh, S. W., You, T., Lee, K. W., Park, J. D., Kang, H. J., Kim, J. G., Kang, E. K., Hong, G., & Suh, K. S. (2014). Fulminant hepatitis linked to dapsone hypersensitivity syndrome requiring urgent living donor liver transplantation: A case report. Pediatric Transplantation, 18(7), E240-E245. https://doi.org/10.1111/petr.12343

@article{986b2789025646eea33c5a584cb9cd43,

title = "Fulminant hepatitis linked to dapsone hypersensitivity syndrome requiring urgent living donor liver transplantation: A case report",

abstract = "Dapsone is a sulfone-type drug used widely for different infectious, immune, and hypersensitivity disorders as an antibacterial treatment alone or in combination for leprosy and sometimes for infected skin lesions. DHS is a severe idiosyncratic adverse reaction with multi-organ involvement. However, acute necrotic hepatitis requiring an emergent LT is rare. Herein, we report a case of 12-yr-old girl who suffered from fulminant hepatitis and multi-organ failure due to DHS for PPD. She was saved by emergent LDLT. A high index of suspicion and rapid diagnosis are necessary not to miss this potentially lethal but rare disease.",

keywords = "Dapsone hypersensitivity syndrome, Fulminant hepatitis, Liver transplant, Pigmented purpuric dermatosis",

author = "Angelica Garcia and Yi, {Nam Joon} and Lee, {Kyoung Bun} and Lee, {Jeong Moo} and Choi, {Young Rok} and Suh, {Suk Won} and Tae You and Lee, {Kwang Woong} and Park, {June Dong} and Kang, {Hyoung Jin} and Kim, {Joon Gon} and Kang, {Eun Kyeong} and Geun Hong and Suh, {Kyung Suk}",

note = "Publisher Copyright: {\textcopyright} 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.",

year = "2014",

doi = "10.1111/petr.12343",

language = "English",

volume = "18",

pages = "E240--E245",

journal = "Pediatric Transplantation",

issn = "1397-3142",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "7",

}

TY - JOUR

T1 - Fulminant hepatitis linked to dapsone hypersensitivity syndrome requiring urgent living donor liver transplantation

T2 - A case report

AU - Garcia, Angelica

AU - Yi, Nam Joon

AU - Lee, Kyoung Bun

AU - Lee, Jeong Moo

AU - Choi, Young Rok

AU - Suh, Suk Won

AU - You, Tae

AU - Lee, Kwang Woong

AU - Park, June Dong

AU - Kang, Hyoung Jin

AU - Kim, Joon Gon

AU - Kang, Eun Kyeong

AU - Hong, Geun

AU - Suh, Kyung Suk

PY - 2014

Y1 - 2014

N2 - Dapsone is a sulfone-type drug used widely for different infectious, immune, and hypersensitivity disorders as an antibacterial treatment alone or in combination for leprosy and sometimes for infected skin lesions. DHS is a severe idiosyncratic adverse reaction with multi-organ involvement. However, acute necrotic hepatitis requiring an emergent LT is rare. Herein, we report a case of 12-yr-old girl who suffered from fulminant hepatitis and multi-organ failure due to DHS for PPD. She was saved by emergent LDLT. A high index of suspicion and rapid diagnosis are necessary not to miss this potentially lethal but rare disease.

AB - Dapsone is a sulfone-type drug used widely for different infectious, immune, and hypersensitivity disorders as an antibacterial treatment alone or in combination for leprosy and sometimes for infected skin lesions. DHS is a severe idiosyncratic adverse reaction with multi-organ involvement. However, acute necrotic hepatitis requiring an emergent LT is rare. Herein, we report a case of 12-yr-old girl who suffered from fulminant hepatitis and multi-organ failure due to DHS for PPD. She was saved by emergent LDLT. A high index of suspicion and rapid diagnosis are necessary not to miss this potentially lethal but rare disease.

KW - Dapsone hypersensitivity syndrome

KW - Fulminant hepatitis

KW - Liver transplant

KW - Pigmented purpuric dermatosis

UR - http://www.scopus.com/inward/record.url?scp=85027928213&partnerID=8YFLogxK

U2 - 10.1111/petr.12343

DO - 10.1111/petr.12343

M3 - Article

C2 - 25156688

AN - SCOPUS:85027928213

SN - 1397-3142

VL - 18

SP - E240-E245

JO - Pediatric Transplantation

JF - Pediatric Transplantation

IS - 7

ER -

Fulminant hepatitis linked to dapsone hypersensitivity syndrome requiring urgent living donor liver transplantation: A case report

Abstract

Bibliographical note

Keywords

Access to Document

Fingerprint

Cite this