Fructose: a lipogenic nutrient implicated in metabolic syndrome and chronic kidney disease

Duk Hee Kang, Takahiko Nakagawa, Richard J. Johnson

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Fructose is a simple sugar that is the primary nutrient in fruits and honey, which are classically considered healthy foods. Fructose is also a major component of refined sugar, which has classically been viewed as a nonnutritional food or “empty calorie.” In the last decades the viewpoint that fructose is simply a caloric source of nutrition has shifted to one that places it at the top of the list for driving diseases such as obesity and diabetes. The new studies have raised important questions related to the optimal diet for subjects with chronic or end-stage kidney disease, in which historic recommendations focused primarily on a restriction of proteins (especially red meats) and high-fat diets. Here we both review the role of fructose in the subject with chronic kidney disease and also make recommendations for management.

Original languageEnglish
Title of host publicationNutritional Management of Renal Disease, Fourth Edition
Number of pages8
ISBN (Electronic)9780128185407
ISBN (Print)9780128185414
StatePublished - 1 Jan 2021

Bibliographical note

Publisher Copyright:
© 2022 Elsevier Inc. All rights reserved.


  • Fructose
  • chronic kidney disease
  • metabolic syndrome
  • nutrition
  • uric acid


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