Frontal lobe gray matter density decreases in bipolar I disorder

In Kyoon Lyoo, Minue J. Kim, Andrew L. Stoll, Christina M. Demopulos, Aimee M. Parow, Stephen R. Dager, Seth D. Friedman, David L. Dunner, Perry F. Renshaw

Research output: Contribution to journalArticlepeer-review

234 Scopus citations


Background This study was conducted to explore differences in gray and white matter density between bipolar and healthy comparison groups using voxel-based morphometry (VBM). Methods Brain magnetic resonance imaging was performed for 39 subjects with bipolar I disorder and 43 comparison subjects. Images were registered into a proportional stereotaxic space and segmented into gray matter, white mater, and cerebrospinal fluid. Statistical parametric mapping was used to calculate differences in gray and white matter density between groups. Results Bipolar subjects had decreased gray matter density in left anterior cingulate gyrus (Brodmann's area [BA] 32, 7.3% decrease), an adjacent left medial frontal gyrus (BA 10, 6.9% decrease), right inferior frontal gyrus (BA 47, 9.2% decrease), and right precentral gyrus (BA 44, 6.2% decrease), relative to comparison subjects. Conclusions The observation of a gray matter density decrease in the left anterior cingulate, which processes emotions, in bipolar subjects is consistent with prior reports that used region-of-interest analytic methods. Decreased gray matter density in the right inferior frontal gyrus, which processes nonverbal and intrinsic functions, supports nondominant hemisphere dysfunction as a component of bipolar disorder.

Original languageEnglish
Pages (from-to)648-651
Number of pages4
JournalBiological Psychiatry
Issue number6
StatePublished - 15 Mar 2004

Bibliographical note

Funding Information:
This study was supported in part by grants from the National Institute of Mental Health (Grant No. MGH58681), the Stanley Medical Research Institute (IKL), the Stanley Foundation Bipolar Disorders Research Grant at McLean Hospital, the Poitras Foundation (ALS, PFR), National Alliance for Research on Schizophrenia and Depression Young Investigator Award, and the Harvard–MIT Clinical Investigator Training Program Award (IKL).


  • Bipolar disorder
  • Brain
  • Frontal lobe
  • Gray matter
  • Magnetic resonance imaging
  • Voxel-based morphometry


Dive into the research topics of 'Frontal lobe gray matter density decreases in bipolar I disorder'. Together they form a unique fingerprint.

Cite this