Frontal glucose hypometabolism in abstinent methamphetamine users

Seog Ju Kim, In Kyoon Lyoo, Jaeuk Hwang, Young Hoon Sung, Ho Young Lee, Dong Soo Lee, Do Un Jeong, Perry F. Renshaw

Research output: Contribution to journalArticlepeer-review

99 Scopus citations


Changes in relative regional cerebral glucose metabolism (rCMRglc) and their potential gender differences in abstinent methamphetamine (MA) users were explored. Relative rCMRglc, as measured by 18F-fluorodeoxyglucose positron emission tomography, and frontal executive functions, as assessed by Wisconsin card sorting test (WCST), were compared between 35 abstinent MA users and 21 healthy comparison subjects. In addition, male and female MA users and their gender-matched comparison subjects were compared to investigate potential gender differences. MA users had lower rCMRglc levels in the right superior frontal white matter and more perseveration and nonperseveration errors in the WCST, relative to healthy comparison subjects. Relative rCMRglc in the frontal white matter correlated with number of errors in the WCST in MA users. In the subanalysis for gender differences, lower rCMRglc in the frontal white matter and more errors in the WCST were found only in male MA users, not in female MA users, relative to their gender-matched comparison subjects. The current findings suggest that MA use causes persistent hypometabolism in the frontal white matter and impairment in frontal executive function. Our findings also suggest that the neurotoxic effect of MA on frontal lobes of the brain might be more prominent in men than in women.

Original languageEnglish
Pages (from-to)1383-1391
Number of pages9
Issue number7
StatePublished - Jul 2005

Bibliographical note

Funding Information:
This work was supported by grants from the Health Technology Infrastructure Development Project of Korea Health Industry Development Institute (03-PJ1-PG3-21300-0069).


  • Brain mapping
  • Frontal lobe
  • Methamphetamine
  • Neuropsychological tests
  • Positron emission tomography
  • Sex characteristics


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