Abstract
The effects of pressure-sensitive adhesives and vehicles on the in vitro permeation of ketorolac and in vivo pharmacokinetics were studied. Duro-Tak 87-2196® showed the highest in vitro permeation profiles, and propylene glycol monolaurate-diethylene glycol monoethyl ether (DGME) (60:40, v/v) and propylene glycol monocaprylate-DGME (60:40, v/v) revealed the most favorable in vitro and in vivo results. The decreased Cmax and prolonged Tmax and half-life were obtained with the ketorolac transdermal systems compared with oral administration, indicating that the ketorolac transdermal systems may have a prolonged effect with reduced toxic event. There was an excellent relationship found between in vitro permeation flux and in vivo AUC0-∞.
Original language | English |
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Pages (from-to) | 69-74 |
Number of pages | 6 |
Journal | Drug Delivery |
Volume | 14 |
Issue number | 2 |
DOIs | |
State | Published - Feb 2007 |
Keywords
- Ketorolac Transdermal Systems
- Pharmacokinetics
- Pressure-Sensitive Adhesives
- Vehicles