Abstract
A zinc bromide complex, formed by the sequential reaction of nitriles with a Reformatsky reagent and terminal alkynes, is used as an intermediate for divergent palladium-catalyzed reactions. The reaction pathway of the intermediate is precisely controlled by the choice of the reaction solvent or the palladium catalyst to quickly form four different aromatic scaffolds - arylamines, aminoindenes, pyrroles, and quinolines - starting from readily available nitriles.
| Original language | English |
|---|---|
| Pages (from-to) | 6435-6438 |
| Number of pages | 4 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 53 |
| Issue number | 25 |
| DOIs | |
| State | Published - 16 Jun 2014 |
Keywords
- aromatics
- divergency
- nitriles
- palladium
- tandem reactions