Formation of four different aromatic scaffolds from nitriles through tandem divergent catalysis

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Abstract

A zinc bromide complex, formed by the sequential reaction of nitriles with a Reformatsky reagent and terminal alkynes, is used as an intermediate for divergent palladium-catalyzed reactions. The reaction pathway of the intermediate is precisely controlled by the choice of the reaction solvent or the palladium catalyst to quickly form four different aromatic scaffolds - arylamines, aminoindenes, pyrroles, and quinolines - starting from readily available nitriles.

Original languageEnglish
Pages (from-to)6435-6438
Number of pages4
JournalAngewandte Chemie - International Edition
Volume53
Issue number25
DOIs
StatePublished - 16 Jun 2014

Keywords

  • aromatics
  • divergency
  • nitriles
  • palladium
  • tandem reactions

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