Formal synthesis of (±)-sedamine through gold(I)-catalyzed intramolecular dehydrative amination of sulfamate esters tethered to allylic alcohols

Yunjeong Park, Jae Sang Ryu

Research output: Contribution to journalArticlepeer-review

Abstract

A concise formal synthesis of (±)-sedamine has been accomplished. The synthesis is straightforward and demonstrates high efficiency. Key steps involve gold(I)-catalyzed cyclization of sulfamate esters tethered to allylic alcohols, sulfamate N-alkylation, and ring-closing metathesis.

Original languageEnglish
Article number153024
JournalTetrahedron Letters
Volume71
DOIs
StatePublished - 11 May 2021

Keywords

  • Cyclic sulfamidate
  • Dehydrative amination
  • Gold
  • Sedamine
  • Silver

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