A new 14-membered macrolactam natural product, fluvirucin B6 (1), was isolated from a marine-derived actinomycete, Nocardiopsis sp. CNQ-115, via HPLC-UV guided isolation. The chemical structure of 1 was elucidated by 1D and 2D NMR spectroscopic data analysis. Compound 1 showed a weak activity against Gram-positive bacteria, whereas it was inactive against Gram-negative bacteria.
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Acknowledgements This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2017R1D1A1B03028172 to S.N.) and by the U.S. National Cancer Institute (NIH) under grant R37CA044848 and instrument grant 1 S10 OD0106400-01A1 (HR-LC-MS, both to W.F.)
© 2018 The Author(s) under exclusive licence to the Japan Antibiotics Research Association.