Fluvirucin B6, a new macrolactam isolated from a marine-derived actinomycete of the genus Nocardiopsis

Alain S. Leutou; Inho Yang; Tu Cam Le; Dongyup Hahn; Kyung Min Lim; Sang Jip Nam; William Fenical

doi:10.1038/s41429-018-0033-3

Fluvirucin B6, a new macrolactam isolated from a marine-derived actinomycete of the genus Nocardiopsis

Alain S. Leutou, Inho Yang, Tu Cam Le, Dongyup Hahn, Kyung Min Lim, Sang Jip Nam, William Fenical

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

A new 14-membered macrolactam natural product, fluvirucin B6 (1), was isolated from a marine-derived actinomycete, Nocardiopsis sp. CNQ-115, via HPLC-UV guided isolation. The chemical structure of 1 was elucidated by 1D and 2D NMR spectroscopic data analysis. Compound 1 showed a weak activity against Gram-positive bacteria, whereas it was inactive against Gram-negative bacteria.

Original language	English
Pages (from-to)	609-612
Number of pages	4
Journal	Journal of Antibiotics
Volume	71
Issue number	6
DOIs	https://doi.org/10.1038/s41429-018-0033-3
State	Published - 1 Jun 2018

Bibliographical note

Funding Information:
Acknowledgements This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2017R1D1A1B03028172 to S.N.) and by the U.S. National Cancer Institute (NIH) under grant R37CA044848 and instrument grant 1 S10 OD0106400-01A1 (HR-LC-MS, both to W.F.)

Publisher Copyright:
© 2018 The Author(s) under exclusive licence to the Japan Antibiotics Research Association.

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title = "Fluvirucin B6, a new macrolactam isolated from a marine-derived actinomycete of the genus Nocardiopsis",

abstract = "A new 14-membered macrolactam natural product, fluvirucin B6 (1), was isolated from a marine-derived actinomycete, Nocardiopsis sp. CNQ-115, via HPLC-UV guided isolation. The chemical structure of 1 was elucidated by 1D and 2D NMR spectroscopic data analysis. Compound 1 showed a weak activity against Gram-positive bacteria, whereas it was inactive against Gram-negative bacteria.",

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doi = "10.1038/s41429-018-0033-3",

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AU - Le, Tu Cam

AU - Hahn, Dongyup

AU - Lim, Kyung Min

AU - Nam, Sang Jip

AU - Fenical, William

N1 - Funding Information: Acknowledgements This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2017R1D1A1B03028172 to S.N.) and by the U.S. National Cancer Institute (NIH) under grant R37CA044848 and instrument grant 1 S10 OD0106400-01A1 (HR-LC-MS, both to W.F.) Publisher Copyright: © 2018 The Author(s) under exclusive licence to the Japan Antibiotics Research Association.

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N2 - A new 14-membered macrolactam natural product, fluvirucin B6 (1), was isolated from a marine-derived actinomycete, Nocardiopsis sp. CNQ-115, via HPLC-UV guided isolation. The chemical structure of 1 was elucidated by 1D and 2D NMR spectroscopic data analysis. Compound 1 showed a weak activity against Gram-positive bacteria, whereas it was inactive against Gram-negative bacteria.

AB - A new 14-membered macrolactam natural product, fluvirucin B6 (1), was isolated from a marine-derived actinomycete, Nocardiopsis sp. CNQ-115, via HPLC-UV guided isolation. The chemical structure of 1 was elucidated by 1D and 2D NMR spectroscopic data analysis. Compound 1 showed a weak activity against Gram-positive bacteria, whereas it was inactive against Gram-negative bacteria.

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Fluvirucin B6, a new macrolactam isolated from a marine-derived actinomycete of the genus Nocardiopsis

Abstract

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