Fluvirucin B6, a new macrolactam isolated from a marine-derived actinomycete of the genus Nocardiopsis

Alain S. Leutou, Inho Yang, Tu Cam Le, Dongyup Hahn, Kyung Min Lim, Sang Jip Nam, William Fenical

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Abstract

A new 14-membered macrolactam natural product, fluvirucin B6 (1), was isolated from a marine-derived actinomycete, Nocardiopsis sp. CNQ-115, via HPLC-UV guided isolation. The chemical structure of 1 was elucidated by 1D and 2D NMR spectroscopic data analysis. Compound 1 showed a weak activity against Gram-positive bacteria, whereas it was inactive against Gram-negative bacteria.

Original languageEnglish
Pages (from-to)609-612
Number of pages4
JournalJournal of Antibiotics
Volume71
Issue number6
DOIs
StatePublished - 1 Jun 2018

Bibliographical note

Funding Information:
Acknowledgements This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2017R1D1A1B03028172 to S.N.) and by the U.S. National Cancer Institute (NIH) under grant R37CA044848 and instrument grant 1 S10 OD0106400-01A1 (HR-LC-MS, both to W.F.)

Publisher Copyright:
© 2018 The Author(s) under exclusive licence to the Japan Antibiotics Research Association.

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