@article{4d45a6448352471dafd58eb09d7435f2,
title = "Fluorogenic probes for disease-relevant enzymes",
abstract = "Traditional biochemical methods for enzyme detection are mainly based on antibody-based immunoassays, which lack the ability to monitor the spatiotemporal distribution and, in particular, the in situ activity of enzymes in live cells and in vivo. In this review, we comprehensively summarize recent progress that has been made in the development of small-molecule as well as material-based fluorogenic probes for sensitive detection of the activities of enzymes that are related to a number of human diseases. The principles utilized to design these probes as well as their applications are reviewed. Specific attention is given to fluorogenic probes that have been developed for analysis of the activities of enzymes including oxidases and reductases, those that act on biomacromolecules including DNAs, proteins/peptides/amino acids, carbohydrates and lipids, and those that are responsible for translational modifications. We envision that this review will serve as an ideal reference for practitioners as well as beginners in relevant research fields.",
author = "Junji Zhang and Xianzhi Chai and He, {Xiao Peng} and Kim, {Hae Jo} and Juyoung Yoon and He Tian",
note = "Funding Information: X. C., J. Z., X. P. H. and H. T. thank the National Natural Science Foundation of China (21788102, 21722801 and 21572058), the Programme of Introducing Talents of Discipline to Universities (B16017) and the Shanghai Rising-Star Program (16QA1401400). The Shanghai Municipal Science and Technology Major Project (2018SHZDZX03) and the international cooperation program of Shanghai Science and Technology Committee (17520750100) are warmly thanked for financially supporting international cooperations. H. J. K. acknowledges the financial support from the National Research Foundation of Korea (NRF 2017R1A2B4006706). J. Y. acknowledges a grant from the National Creative Research Initiative programs of the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) (no. 2012R1A3A2048814). Funding Information: This work was financially supported by the National Natural Science Foundation of China (21620102005, 91527306, 51390483). Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",
year = "2019",
month = jan,
day = "21",
doi = "10.1039/c7cs00907k",
language = "English",
volume = "48",
pages = "683--722",
journal = "Chemical Society Reviews",
issn = "0306-0012",
publisher = "Royal Society of Chemistry",
number = "2",
}
