Fluorescent sensing of triphosphate nucleotides via anthracene derivatives

Ha Na Kim, Jong Hun Moon, Sook Kyung Kim, Ji Young Kwon, Yun Jung Jang, Jin Yong Lee, Juyoung Yoon

Research output: Contribution to journalArticlepeer-review

59 Scopus citations

Abstract

A nucleotide is composed of a nucleobase, a five-carbon sugar, and phosphate groups. Recognition of these three sites can provide useful information for the development of selective fluorescent receptors for a specific nucleotide. In this paper, anthracene derivatives with two imidazolium groups at the 1,8- and 9,10-positions, quaternary ammonium groups, or the boronic acid group were examined for the recognition of nucleotides, such as ATP, GTP, CTP, TTP, UTP, ADP, and AMP, via fluorescence changes. The anthracene group provides the interaction between the bases of the nucleotides. The imidazolium and quaternary ammonium groups induce hydrogen bonding interactions with the phosphate groups of the nucleotides. The boronic acid group can interact with the ribose of the nucleotides.

Original languageEnglish
Pages (from-to)3805-3811
Number of pages7
JournalJournal of Organic Chemistry
Volume76
Issue number10
DOIs
StatePublished - 20 May 2011

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