Fluorescent probes for the detection of disease-associated biomarkers

Wei Tao Dou, Hai Hao Han, Adam C. Sedgwick, Guo Biao Zhu, Yi Zang, Xin Rong Yang, Juyoung Yoon, Tony D. James, Jia Li, Xiao Peng He

Research output: Contribution to journalReview articlepeer-review

78 Scopus citations


Fluorescent probes have emerged as indispensable chemical tools to the field of chemical biology and medicine. The ability to detect intracellular species and monitor physiological processes has not only advanced our knowledge in biology but has provided new approaches towards disease diagnosis. In this review, we detail the design criteria and strategies for some recently reported fluorescent probes that can detect a wide range of biologically important species in cells and in vivo. In doing so, we highlight the importance of each biological species and their role in biological systems and for disease progression. We then discuss the current problems and challenges of existing technologies and provide our perspective on the future directions of the research area. Overall, we hope this review will provide inspiration for researchers and prove as useful guide for the development of the next generation of fluorescent probes.

Original languageEnglish
Pages (from-to)853-878
Number of pages26
JournalScience Bulletin
Issue number8
StatePublished - 30 Apr 2022


  • Biomarker detection
  • Chemical biology
  • Fluorescence imaging
  • Fluorescent probes


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