TY - JOUR
T1 - Fluorescent Probes Containing Selenium as a Guest or Host
AU - Wu, Di
AU - Chen, Liyan
AU - Kwon, Nahyun
AU - Yoon, Juyoung
N1 - Funding Information:
We are grateful to the editor for his kind invitation to submit this review. This study was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIP) (no. 2012R1A3A2048814).
Publisher Copyright:
© 2016 Elsevier Inc.
PY - 2016/11/10
Y1 - 2016/11/10
N2 - Selenium is an important trace element in living systems. Proteins incorporating selenium have a wide range of biological effects, ranging from anti-oxidant and anti-inflammatory effects to the production of active thyroid hormones. In the past decades, selenium has drawn enormous attention because of its important role in biology, which can be ascribed partly if not solely to its redox and hard and soft donor properties. With the use of chemical mimicry, a large number of selenium-related fluorescent probes have been developed for monitoring physiological and pathological processes. This review, which summarizes recent progress made in this area, comprises two major sections. In the first section, fluorescent probes for selenium-containing species, such as selenocysteine (Sec), hydrogen selenide, thioredoxin reductases (TrxRs), and selenite, are described. This is followed by a discussion of fluorescent probes that contain selenium and detect reactive oxygen, nitrogen, and sulfur species, as well as cations and anions.
AB - Selenium is an important trace element in living systems. Proteins incorporating selenium have a wide range of biological effects, ranging from anti-oxidant and anti-inflammatory effects to the production of active thyroid hormones. In the past decades, selenium has drawn enormous attention because of its important role in biology, which can be ascribed partly if not solely to its redox and hard and soft donor properties. With the use of chemical mimicry, a large number of selenium-related fluorescent probes have been developed for monitoring physiological and pathological processes. This review, which summarizes recent progress made in this area, comprises two major sections. In the first section, fluorescent probes for selenium-containing species, such as selenocysteine (Sec), hydrogen selenide, thioredoxin reductases (TrxRs), and selenite, are described. This is followed by a discussion of fluorescent probes that contain selenium and detect reactive oxygen, nitrogen, and sulfur species, as well as cations and anions.
KW - fluorescent probes
KW - fluorescent probes containing selenium
KW - selenium
UR - http://www.scopus.com/inward/record.url?scp=85008258246&partnerID=8YFLogxK
U2 - 10.1016/j.chempr.2016.10.005
DO - 10.1016/j.chempr.2016.10.005
M3 - Review article
AN - SCOPUS:85008258246
SN - 2451-9308
VL - 1
SP - 674
EP - 698
JO - Chem
JF - Chem
IS - 5
ER -