Fluorescent molecular logic gates using microfluidic devices

Songzi Kou, Na Lee Han, Danny Van Noort, K. M.K. Swamy, Hyun Kim So, Hyun Soh Jung, Kang Mu Lee, Seong Won Nam, Juyoung Yoon, Sungsu Park

Research output: Contribution to journalArticlepeer-review

171 Scopus citations


Starting gate: A molecular logic gate is based on chemosensors that change their fluorescence intensity in response to various inputs (pH, metal ions) in a microfluidic system. A combinatorial circuit, such as a half adder (see picture), uses fluorescein (green) and rhodamine B (red) derivatives that respond to pH. A logic gate with a protein and Cu2+ ions as inputs is also described. (Figure Presented).

Original languageEnglish
Pages (from-to)872-876
Number of pages5
JournalAngewandte Chemie - International Edition
Issue number5
StatePublished - 2008


  • Chemosensors
  • Fluorescence
  • Logic gates
  • Microfluidics
  • Molecular devices


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